Wake Forest vs Clemson Prediction, Odds, Spread, Date & Start Time for College Football Week 12 Game
By Larry Rupp

Wake Forest vs Clemson Week 12 Game Info
Week 12 College Football Game
No. 12 Wake Forest Demon Deacons (9-1, 6-0 ACC) vs. Clemson Tigers (7-3, 5-2 ACC)
Date: Saturday, November 20, 2021
Time: 12:00 p.m. EST
Venue: Memorial Stadium – Clemson, SC
Coverage: ESPN
Wake Forest vs Clemson Spread & Odds
All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.
Moneyline: WAKE: (+148) | CLEM: (-184)
Spread: WAKE: +3.5 (-110) | CLEM: -3.5 (-110)
Total: 55.5 – Over: (-110) | Under: (-110)
Wake Forest vs Clemson Prediction & Pick
All NCAAF predictions & expert picks are according to numberFire.
Prediction: Clemson wins (50.8%)
Wake Forest vs Clemson Head-to-Head Record & Betting Trends
- Clemson is 68-17-1 straight up in 86 all-time head-to-head matchups against Wake Forest.
- Clemson defeated Wake Forest, 37-13, during their most recent meeting on Sept. 12, 2020.
- Wake Forest is 0-10 straight up in its last 10 games against Clemson.
- The total has hit the over in five of Wake Forest's last six games.
- Clemson is 2-9 against the spread (ATS) in its last 11 games.
- The total has hit the under in nine of Clemson's last 13 games against Wake Forest.
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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.