Saturday Night Fantasy Football Picks: Start 'Em, Sit 'Em for 49ers vs Cardinals

Kyler Murray fantasy outlook makes him a top-five start in Week 16.
Kyler Murray fantasy outlook makes him a top-five start in Week 16. / Norm Hall/Getty Images

The San Francisco 49ers and Arizona Cardinals will face off in a battle between two NFC West squads. Arizona enters this one as a 5-point favorite, according to FanDuel Sportsbook's NFL odds.

If you need some help with your fantasy lineups, here's some start 'em, sit 'em advice for this Week 16 showdown.

Jeff Wilson Jr. Fantasy

Start Jeff Wilson Jr., RB, San Francisco 49ers: With Raheem Mostert out for the year, Jeff Wilson Jr. should be in line for a feature back role in the fantasy championships. Arizona isn't exactly the easiest matchup, surrendering bottom-12 PPR production to opposing RBs, but that's not a reason to bench Wilson here. Likely to see some heavy volume, Wilson is a solid RB2 option in the fantasy championships.

Kyler Murray Fantasy

Start Kyler Murray, QB, Arizona Cardinals: Kyler Murray has been the top-scoring QB in fantasy football all year long. Even against a stout 49ers' defense, there's no reason to believe Murray will slow down in Week 16. He torched a much healthier version of this defense back in Week 1, putting up 26.3 fantasy points. Expect another dominant showing from fantasy's QB1.

Jordan Reed Fantasy

Sit Jordan Reed, San Francisco 49ers: With George Kittle set to return, Jordan Reed is once again unplayable for fantasy purposes. Though one might expect San Francisco to ease Kittle back in, that certainly didn't happen the last time he returned from injury. Kittle returned from a two-week absence in Week 4, catching all 15 of his targets for 183 yards and a TD. Kittle's return should instantly phase Reed of out of the offense.

Christian Kirk Fantasy

Sit Christian Kirk, WR, Arizona Cardinals: Christian Kirk has shown flashes this year, but he's really struggled to do much of anything recently. In fact, he hasn't put up more than 50 receiving yards since Week 9. Though he's got weekly boom-or-bust upside, Kirk isn't someone you can trust in the fantasy championships.

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Max Staley is not a FanDuel employee. In addition to providing DFS gameplay advice, Max Staley also participates in DFS contests on FanDuel using his personal account, username mstaley1212. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.