NFL Week 6 Picks & Predictions Against the Spread From The Duel Staff

The 2021 NFL season has gotten off to a hot start, and the editors at The Duel are making against the spread (ATS) picks for each game. You can follow along, check it out, or fade us throughout the season.

NFL Week 6 Predictions

We have full betting previews for each matchup below along with the betting lines from FanDuel Sportsbook. We’ll update this with records on a weekly basis and make picks for every round of the playoffs through the Super Bowl.

NFL Expert Picks Against the Spread

Note: All betting lines and odds are from FanDuel Sportsbook, as of Wednesday, Oct. 13 at 4 p.m. EST.

Buccaneers vs Eagles Picks

Buccaneers (-7) vs Eagles (+7) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Eagles
- Taylor McKillop: Buccaneers
- David Kaestle: Buccaneers
- Isaiah De Los Santos: Buccaneers
- Jason Schandl: Eagles
- Max Staley: Buccaneers

Dolphins vs Jaguars Picks

Dolphins (-3) vs Jaguars (+3) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Jaguars
- Taylor McKillop: Dolphins
- David Kaestle: Dolphins
- Isaiah De Los Santos: Dolphins
- Jason Schandl: Dolphins
- Max Staley: Dolphins

Texans vs Colts Picks

Texans (+9.5) vs Colts (-9.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Colts
- Taylor McKillop: Texans
- David Kaestle: Texans
- Isaiah De Los Santos: Texans
- Jason Schandl: Colts
- Max Staley: Texans

Packers vs Bears Picks

Packers (-4.5) vs Bears (+4.5) Betting Preview

- Brian Giuffra: Packers
- Taylor McKillop: Packers
- David Kaestle: Packers
- Isaiah De Los Santos: Packers
- Jason Schandl: Packers
- Max Staley: Bears

Chiefs vs Washington Picks

Chiefs (-7) vs Washington (+7) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Chiefs
- Taylor McKillop: Washington
- David Kaestle: Washington
- Isaiah De Los Santos: Washington
- Jason Schandl: Washington
- Max Staley: Washington

Vikings vs Panthers Picks

Vikings (-1) vs Panthers (+1) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Panthers
- Taylor McKillop: Panthers
- David Kaestle: Panthers
- Isaiah De Los Santos: Vikings
- Jason Schandl: Panthers
- Max Staley: Vikings

Chargers vs Ravens Picks

Chargers (-3) vs Ravens (+3) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Ravens
- Taylor McKillop: Ravens
- David Kaestle: Ravens
- Isaiah De Los Santos: Ravens
- Jason Schandl: Ravens
- Max Staley: Chargers

Bengals vs Lions Picks

Bengals (-3.5) vs Lions (+3.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Bengals
- Taylor McKillop: Bengals
- David Kaestle: Lions
- Isaiah De Los Santos: Bengals
- Jason Schandl: Bengals
- Max Staley: Lions

Rams vs Giants Picks

Rams (-10.5) vs Giants (+10.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Rams
- Taylor McKillop: Giants
- David Kaestle: Rams
- Isaiah De Los Santos: Rams
- Jason Schandl: Giants
- Max Staley: Giants

Cardinals vs Browns Picks

Cardinals (+3) vs Browns (-3) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Browns
- Taylor McKillop: Cardinals
- David Kaestle: Cardinals
- Isaiah De Los Santos: Cardinals
- Jason Schandl: Cardinals
- Max Staley: Browns

Raiders vs Broncos Picks

Raiders (+3.5) vs Broncos (-3.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Broncos
- Taylor McKillop: Broncos
- David Kaestle: Raiders
- Isaiah De Los Santos: Raiders
- Jason Schandl: Broncos
- Max Staley: Raiders

Cowboys vs Patriots Picks

Cowboys (-4) vs Patriots (+4) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Cowboys
- Taylor McKillop: Cowboys
- David Kaestle: Cowboys
- Isaiah De Los Santos: Cowboys
- Jason Schandl: Patriots
- Max Staley: Cowboys

Seahawks vs Steelers Picks

Seahawks (+4.5) vs Steelers (-4.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Steelers
- Taylor McKillop: Steelers
- David Kaestle: Steelers
- Isaiah De Los Santos: Steelers
- Jason Schandl: Steelers
- Max Staley: Seahawks

Bills vs Titans Picks

Bills (-6) vs Titans (+6) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Titans
- Taylor McKillop: Bills
- David Kaestle: Bills
- Isaiah De Los Santos: Bills
- Jason Schandl: Titans
- Max Staley: Bills

Staff Records (ATS):
- Brian Giuffra: 36-27 (57.14%)
- Isaiah De Los Santos: 44-34 (56.41%)
- Max Staley: 43-35 (55.13%)
- Jason Schandl: 37-41 (47.44%)
- Taylor McKillop: 35-43 (44.87%)
- David Kaestle: 32-46 (41.03%)

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David Kaestle is not a FanDuel employee. In addition to providing DFS gameplay advice, David also participates in DFS contests on FanDuel using his personal account, username davekaestle. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.