NFL Week 5 Picks & Predictions Against the Spread From The Duel Staff

The 2021 NFL season has gotten off to a hot start, and the editors at The Duel are making against the spread (ATS) picks for each game. You can follow along, check it out, or fade us throughout the season.

NFL Week 5 Predictions

We have full betting previews for each matchup below along with the betting lines from FanDuel Sportsbook. We’ll update this with records on a weekly basis and make picks for every round of the playoffs through the Super Bowl.

NFL Expert Picks Against the Spread

Note: All betting lines and odds are from FanDuel Sportsbook, as of Tuesday, Oct. 5 at 4 p.m. EST.

Rams vs Seahawks Picks

Rams (-1.5) vs Seahawks (+1.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Rams
- Taylor McKillop: Seahawks
- David Kaestle: Seahawks
- Isaiah De Los Santos: Rams
- Jason Schandl: Rams
- Max Staley: Rams

Jets vs Falcons Picks

Jets (+3) vs Falcons (-3) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Falcons
- Taylor McKillop: Jets
- David Kaestle: Falcons
- Isaiah De Los Santos: Jets
- Jason Schandl: Falcons
- Max Staley: Falcons

Eagles vs Panthers Picks

Eagles (+3.5) vs Panthers (-3.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Eagles
- Taylor McKillop: Panthers
- David Kaestle: Panthers
- Isaiah De Los Santos: Panthers
- Jason Schandl: Eagles
- Max Staley: Eagles

Dolphins vs Buccaneers Picks

Dolphins (+10.5) vs Buccaneers (-10.5) Betting Preview

- Brian Giuffra: Buccaneers
- Taylor McKillop: Buccaneers
- David Kaestle: Buccaneers
- Isaiah De Los Santos: Buccaneers
- Jason Schandl: Dolphins
- Max Staley: Dolphins

Saints vs Washington Picks

Saints (-2.5) vs Washington (+2.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Saints
- Taylor McKillop: Washington
- David Kaestle: Washington
- Isaiah De Los Santos: Washington
- Jason Schandl: Saints
- Max Staley: Saints

Titans vs Jaguars Picks

Titans (-4) vs Jaguars (+4) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Titans
- Taylor McKillop: Titans
- David Kaestle: Titans
- Isaiah De Los Santos: Titans
- Jason Schandl: Jaguars
- Max Staley:Jaguars

Lions vs Vikings Picks

Lions (+7.5) vs Vikings (-7.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Lions
- Taylor McKillop: Vikings
- David Kaestle: Vikings
- Isaiah De Los Santos: Lions
- Jason Schandl: Lions
- Max Staley: Vikings

Broncos vs Steelers Picks

Broncos (+1.5) vs Steelers (-1.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Steelers
- Taylor McKillop: Steelers
- David Kaestle: Steelers
- Isaiah De Los Santos: Broncos
- Jason Schandl: Steelers
- Max Staley: Broncos

Packers vs Bengals Picks

Packers (-3) vs Bengals (+3) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Packers
- Taylor McKillop: Packers
- David Kaestle: Packers
- Isaiah De Los Santos: Packers
- Jason Schandl: Bengals
- Max Staley: Packers

Patriots vs Texans Picks

Patriots (-9) vs Texans (+9) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Patriots
- Taylor McKillop: Patriots
- David Kaestle: Patriots
- Isaiah De Los Santos: Texans
- Jason Schandl: Texans
- Max Staley: Texans

Bears vs Raiders Picks

Bears (+5.5) vs Raiders (-5.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Raiders
- Taylor McKillop: Raiders
- David Kaestle: Raiders
- Isaiah De Los Santos: Raiders
- Jason Schandl: Bears
- Max Staley: Raiders

Browns vs Chargers Picks

Browns (+1) vs Chargers (-1) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Browns
- Taylor McKillop: Browns
- David Kaestle: Chargers
- Isaiah De Los Santos: Chargers
- Jason Schandl: Browns
- Max Staley: Browns

Giants vs Cowboys Picks

Giants (+7) vs Cowboys (-7) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Cowboys
- Taylor McKillop: Cowboys
- David Kaestle: Giants
- Isaiah De Los Santos: Cowboys
- Jason Schandl: Giants
- Max Staley: Cowboys

49ers vs Cardinals Picks

49ers (+5.5) vs Cardinals (-5.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Cardinals
- Taylor McKillop: Cardinals
- David Kaestle: 49ers
- Isaiah De Los Santos: Cardinals
- Jason Schandl: Cardinals
- Max Staley: 49ers

Bills vs Chiefs Picks

Bills (+3) vs Chiefs (-3) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Chiefs
- Taylor McKillop: Chiefs
- David Kaestle: Chiefs
- Isaiah De Los Santos: Bills
- Jason Schandl: Bills
- Max Staley: Bills

Colts vs Ravens Picks

Colts (+7) vs Ravens (-7) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Colts
- Taylor McKillop: Ravens
- David Kaestle: Ravens
- Isaiah De Los Santos: Colts
- Jason Schandl: Colts
- Max Staley: Ravens

Staff Records (ATS):
- Max Staley: 35-28 (55.56%)
- Brian Giuffra: 26-22 (54.17%)
- Isaiah De Los Santos: 33-30 (52.38%)
- Taylor McKillop: 31-32 (49.21%)
- David Kaestle: 28-35 (44.44%)
- Jason Schandl: 27-36 (42.86%)

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David Kaestle is not a FanDuel employee. In addition to providing DFS gameplay advice, David also participates in DFS contests on FanDuel using his personal account, username davekaestle. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.