49ers vs Titans Prediction, Odds, Spread, Over/Under & Betting Trends for NFL Week 16 Thursday Night Football

49ers vs Titans Week 16 Game Info

NFL Regular Season — Week 16 Game
San Francisco 49ers (8-6, 5-2 Away) vs. Tennessee Titans (9-5, 5-2 Home)
Date: Thursday, December 23, 2021
Time: 8:20 p.m. EST
Venue: Nissan Stadium — Nashville, TN
Coverage: NFL Network

49ers vs Titans Odds & Spread

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (-184) | TEN: (+154)
Spread: SF: -3.5 (-110) | TEN: +3.5 (-110)
Total: 44.5 — Over: (-110) | Under: (-110)
Odds to Win Super Bowl LVI: SF: (+2800) | TEN: (+2600)

49ers vs Titans Prediction & Pick

All NFL predictions and picks are from numberFire's projection model and will be updated when available.
Prediction: San Francisco 49ers in (64.3%)

49ers vs Titans Betting Trends

- San Francisco is 1-7-1 against the spread (ATS) in its last nine games against Tennessee.
- Tennessee is 2-4 ATS in its last six games this season.
- The total has hit the under in four of San Francisco's last six games.
- The total has hit the under in five of Tennessee's last five home games.

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Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.