The Duel

Week 10 Fantasy Picks: Start 'Em, Sit 'Em for 49ers vs Saints

Larry Rupp
Drew Bree's ability to pick apart defenses makes him a great start in Week 10.
Drew Bree's ability to pick apart defenses makes him a great start in Week 10. / Mike Ehrmann/Getty Images

The New Orleans Saints (6-2) will look to win their sixth consecutive game when they host the San Francisco 49ers (4-5) in Week 10 NFL action. These are two teams that have suffered injures to some pivotal players, but this matchup still features a multitude of fantasy football gamechangers.

If you need help with your fantasy football lineups, here's some start 'em, sit 'em advice for the Week 10 49ers-Saints showdown.

Who Should I Start Fantasy Football

Start Jordan Reed, TE, San Francisco 49ers: Jordan Reed was activated off the injured reserve last week, but hauled in 1 of 2 targets for just 3 yards in a game where he only played in 23% of the offensive snaps. Reed should play more this week as he has had time to get fully healthy and could become a top target for struggling quarterback Nick Mullens. Reed draws a decent matchup in Week 10 as the Saints' defense has given up a touchdown to six different tight ends so far this season. If Reed is able to find space over the middle of the field, he could be riddled with targets as Mullens will look to get the ball out as early as he can against this Saints dangerous defensive line.

Start Drew Brees, QB, New Orleans Saints: Drew Brees is hot and coming off a game in which he threw a season-high 4 touchdowns and completed 81.25 percent of his passes. He hasn't thrown an interception since Week 5 and now faces a 49ers' defense that just got torched by Aaron Rodgers. Overall, the 49ers are giving up 10.3 yards per pass completion (No. 15 in the NFL) and allowed 26 passing touchdowns (T-No. 19 in the NFL). With a fully healthy stable of offensive weapons now available, Brees should be able to pick apart this 49ers' defense and secure another big fantasy football performance.

Sit Jerick McKinnon and Jamychal Hasty, RBs, San Francisco 49ers: Jamychal Hasty was expected to be used as a workhorse running back last week, but it was Jerick McKinnon that gathered 68 scrimmage yards on 15 touches to lead the backfield. Heading into this week, it is likely McKinnon is the head back once again, but 49ers' Head Coach Kyle Shanahan has built a reputation of being unpredictable. No matter who starts, this is a horrible matchup as the Saints' defense is only giving up 80.2 rushing yards per game this season (No. 2 in the NFL). Unless you are in dire need of a starting running back, it would be smart to avoid these players this week as the 49ers will likely have to try and win this game through the air.

Sit Jared Cook, TE, New Orleans Saints: Jared Cook is in need of a bounce-back game after catching just 2 passes for 30 yards last week, but this is not the matchup for that to happen. The 49ers' defense is among the best in the league when it comes to defending opposing tight ends. They have given up just 307 yards (No. 5 in the NFL) and 2 touchdowns (T-No. 5 in the NFL) to opposing tight ends all season. The Saints have recently begun to spread the ball around with players like Michael Thomas back from injury, which means Cook may not see as many targets as he has been. While Cook still has top-10 tight end potential for the rest of the season, he is not worthy of a start this week.

SIGN UP AND GET AN INSTANT DEPOSIT BONUS UP TO 500! We'll match 20% of your first deposit on FanDuel Fantasy Sports. Max bonus $500

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.