Astros vs Marlins Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 7:12 p.m.

MLB action on Wednesday includes the Houston Astros facing the Miami Marlins.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Astros vs Marlins Game Info

• Houston Astros (49-54) vs. Miami Marlins (52-50)
• Date: Wednesday, July 22, 2026
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and Marlins.TV

Astros vs Marlins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-116) | MIA: (-102)
• Spread: HOU: +1.5 (-194) | MIA: -1.5 (+160)
• Total: 8 -- Over: (-118) | Under: (-104)

Astros vs Marlins Probable Starting Pitchers

Probable Pitchers: Peter Lambert (Astros) - 8-5, 3.03 ERA vs Sandy Alcantara (Marlins) - 10-5, 3.89 ERA

The probable starters are Peter Lambert (8-5) for the Astros and Sandy Alcantara (10-5) for the Marlins. Lambert's team is 10-6-0 against the spread in his starts this season. Lambert's team has a record of 2-3 this season when he starts and they are the favorite on the moneyline. When Alcantara starts, the Marlins are 14-7-0 against the spread. The Marlins have a 6-4 record in Alcantara's 10 starts this season when they were the underdog on the moneyline.

Astros vs Marlins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Marlins win (57.2%)

Astros vs Marlins Moneyline

• Miami is a -102 underdog on the moneyline, while Houston is a -116 favorite at home.

Astros vs Marlins Spread

• The Marlins are 1.5-run favorites against the spread for this matchup with the Astros. The Marlins are +160 to cover, while the Astros are -194 to cover as a 1.5-run underdog on the runline.

Astros vs Marlins Over/Under

• A total of 8 runs has been set for the Astros-Marlins contest on July 22, with the over available at -118 and the under at -104.

Bet on Houston Astros vs. Miami Marlins on FanDuel today!

Astros vs Marlins Betting Trends

• The Astros have been victorious in 17, or 45.9%, of the 37 contests they have been chosen as favorites in this season.
• This season Houston has been victorious 14 times in 32 chances when named as a favorite of at least -116 on the moneyline.
• The Astros' games have gone over the total in 54 of their 103 opportunities.
• The Astros have an against the spread record of 49-54-0 in 103 games with a line this season.
• The Marlins have won 37% of the games this season they were the underdog on the moneyline (20-34).
• Miami is 17-28 (winning just 37.8% of its games) when playing as a moneyline underdog of -102 or longer.
• The Marlins have played in 101 games with an over/under set, and have combined with opponents to go over the total 52 times (52-47-2).
• The Marlins have covered 52.5% of their games this season, going 53-48-0 against the spread.

Astros Player Leaders

• Yordan Alvarez has 120 hits and an OBP of .432 to go with a slugging percentage of .649. All three of those stats are best among Houston hitters this season. He has a .326 batting average, as well.
• Among qualified hitters in baseball, he ranks second in batting average, first in on-base percentage, and first in slugging.
• Alvarez has hit safely in eight straight games. In his last 10 outings he is hitting .395 with four doubles, four home runs, seven walks and eight RBIs.
• Isaac Paredes is hitting .260 with 18 doubles, a triple, 13 home runs and 39 walks. He's slugging .429 with an on-base percentage of .352.
• His batting average is 61st among qualified players, his on-base percentage 47th, and his slugging percentage 74th.
• Paredes has picked up a hit in seven games in a row. During his last 10 games he is hitting .333 with two doubles, a triple, a home run, five walks and six RBIs.
• Christian Walker has collected 86 base hits, an OBP of .310 and a slugging percentage of .454 this season.
• Jose Altuve has 12 home runs, 29 RBI and a batting average of .232 this season.

Marlins Player Leaders

• Otto Lopez has a slugging percentage of .501 and has 130 hits, both team-high figures for the Marlins. He's batting .332 and with an on-base percentage of .368.
• Including all the qualifying hitters in MLB, he is first in batting average, 23rd in on-base percentage and 22nd in slugging percentage.
• Liam Hicks has nine doubles, a triple, 14 home runs and 34 walks while batting .285. He's slugging .453 with an on-base percentage of .359.
• Including all qualifying hitters, his batting average places him 23rd, his on-base percentage ranks 34th, and he is 55th in slugging.
• Xavier Edwards has put up an on-base percentage of .375, a team-high for the Marlins.
• Javier Sanoja is batting .275 with 19 doubles, two triples, three home runs and 14 walks.

Astros vs Marlins Head to Head

• 7/21/2026: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/20/2026: 8-5 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/6/2025: 6-4 MIA (Favorite: Marlins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/5/2025: 7-3 HOU (Favorite: Marlins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/4/2025: 8-2 HOU (Favorite: Marlins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/11/2024: 6-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -180, Underdog Moneyline: +152)
• 7/10/2024: 9-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 7/9/2024: 4-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 8/16/2023: 12-5 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/15/2023: 6-5 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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