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Colts vs 49ers Prediction, Odds, Spread, Over/Under & Betting Trends for NFL Week 7 Sunday Night Football Game

Devon Platana
Indianapolis Colts vs San Francisco 49ers prediction, odds, spread, over/under and betting trends for NFL Week 7 game.
Indianapolis Colts vs San Francisco 49ers prediction, odds, spread, over/under and betting trends for NFL Week 7 game. / Justin Casterline/GettyImages
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Colts vs 49ers Week 7 Game Info

NFL Regular Season — Week 7 Game
Indianapolis Colts (2-4, 1-2 Away) vs. San Francisco 49ers (2-3, 0-2 Home)
Date: Sunday, October 24, 2021
Time: 8:20 p.m. EST
Venue: Levi's Stadium — Santa Clara, CA
Coverage: NBC

Colts vs 49ers Odds & Spread

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: IND: (+156) | SF: (-186)
Spread: IND: +4 (-114) | SF: -4 (-106)
Total: 42.5 — Over: (-114) | Under: (-106)
Public (Spread) Betting Percentages via oddsFire: IND: (N/A) | SF: (N/A)
Odds to Win Super Bowl LVI: IND: (+10000) | SF: (+4500)

Colts vs 49ers Prediction & Pick

All NFL predictions and picks are from numberFire's projection model.
Prediction: San Francisco 49ers Win (50.4%)

Colts vs 49ers Betting Trends

- Indianapolis 4-1 against the spread (ATS) in its last five games.
- San Francisco is 1-4 ATS in its last five games this season.
- The total has hit the over in five of Indianapolis' last six road games.
- The total has hit the over in five of San Francisco's last six games against AFC South opponents.


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Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.

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