49ers vs Cardinals Predictions and Expert Picks for Week 16 Saturday Night Football

The Arizona Cardinals were able to shock the defending NFC-Champion San Francisco 49ers Week 1, beating them by four points on the road in the opening weekend. A lot has changed since ahead of the Week 16 rematch in Arizona, with the Cards as the playoff hopefuls and the Niners looking towards 2021.

Injuries have impacted San Francisco's season, but injuries or not, division games are always tough. The experts have all the picks and predictions in store as the 49ers eye their revenge and the Cardinals eye a wildcard berth.

49ers vs Cardinals Picks Week 16

CBS Sports picks are from their panel of experts, numberFire picks are from their NFL game projections, Sporting News picks are from Vinnie Iyer and betting favorites are from FanDuel Sportsbook's Week 16 NFL odds.

Winner:
CBS Sports: Cardinals (4)
numberFire: Cardinals
Sporting News: Cardinals
Betting Favorite: Cardinals -5.5

Against the Spread:
CBS Sports: Cardinals (3), 49ers (1)
Sporting News: 49ers

None of the experts are going as far to say the 49ers will win, especially on a third-string quarterback, but two of them do have San Francisco covering the 5.5-point spread.

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Michael Obermuller is not a FanDuel employee. In addition to providing DFS gameplay advice, Michael Obermuller also participates in DFS contests on FanDuel using his personal account, username king_mizzard. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.