NFL - Odds & Predictions

49ers vs Cardinals Prediction, Odds, Spread, Over/Under & Betting Trends for NFL Week 5 Game on FanDuel

Larry Rupp
San Francisco 49ers vs Arizona Cardinals prediction, odds, spread, over/under and betting trends for NFL Week 5 game.
San Francisco 49ers vs Arizona Cardinals prediction, odds, spread, over/under and betting trends for NFL Week 5 game. / Harry How/Getty Images
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49ers vs Cardinals Week 5 Game Info

NFL Regular Season — Week 5 Game
San Francisco 49ers (2-2, 2-0 Away) vs. Arizona Cardinals (4-0, 1-0 Home)
Date: Sunday, October 10, 2021
Time: 4:25 p.m. EST
Venue: State Farm Stadium — Glendale, AZ
Coverage: FOX

49ers vs Cardinals Odds & Spread

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (+194) | ARI: (-235)
Spread: SF: +5.5 (-114) | ARI: -5.5 (-106)
Total: 48.5 — Over: (-108) | Under: (-112)
Public (Spread) Betting Percentages via oddsFire: SF: (N/A) | ARI: (N/A)
Odds to Win Super Bowl LVI: SF: (+1700) | ARI: (+1600)

49ers vs Cardinals Prediction & Pick

All NFL predictions and picks are from numberFire's projection model and will be updated when available.
Prediction: Cardinals to Win (70.8%)

49ers vs Cardinals Betting Trends

- San Francisco is 3-9 straight up in its last 12 games against Arizona.
- The total has hit the under in five of San Francisco's last seven games against an NFC West opponent.
- Arizona is 5-1-1 against the spread (ATS) in its last seven games against San Francisco.
- The total has hit the over in six of Arizona's last seven home games.


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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

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