49ers vs Lions Game Info
49ers vs Lions Odds & Spread
All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (-420) | DET: (+330)
Spread: SF: -8.5 (-110) | DET: +8.5 (-110)
Total: 45.5 — Over: (-115) | Under: (-105)
Public (Spread) Betting Percentages via oddsFire: SF: (55%) | DET: (45%)
Odds to Win Super Bowl LVI: SF: (+1300) | DET: (+20000)
49ers vs Lions Prediction & Pick
All NFL predictions and picks are from numberFire's projection model.
Prediction: 49ers win (71.8%)
49ers vs Lions Betting Trends
- San Francisco is 10-1 straight up in its last 11 games against Detroit.
- Detroit is 1-11 straight up in its last 12 home games.
- The total has hit the under in six of San Francisco's last nine home games against Detroit.
- The total has hit the under in four of Detroit's last five games against NFC West opponents.
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Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.