49ers vs Lions Prediction, Odds, Spread, Over/Under & Betting Trends for NFL Week 1 Game on FanDuel Sportsbook

Devon Platana
San Francisco 49ers vs Detroit Lions prediction, odds, spread, over/under and betting trends for NFL Week 1 Game.
San Francisco 49ers vs Detroit Lions prediction, odds, spread, over/under and betting trends for NFL Week 1 Game. / Michael Zagaris/Getty Images
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49ers vs Lions Game Info

NFL Regular Season — Week 1 Game
San Francisco 49ers (0-0, 0-0 Away) vs. Detroit Lions (0-0, 0-0 Home)
Date: Sunday, September 12, 2021
Time: 1:00 p.m. EST
Venue: Ford Field — Detroit, MI
Coverage: FOX

49ers vs Lions Odds & Spread

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (-420) | DET: (+330)
Spread: SF: -8.5 (-110) | DET: +8.5 (-110)
Total: 45.5 — Over: (-115) | Under: (-105)
Public (Spread) Betting Percentages via oddsFire: SF: (55%) | DET: (45%)
Odds to Win Super Bowl LVI: SF: (+1300) | DET: (+20000)

49ers vs Lions Prediction & Pick

All NFL predictions and picks are from numberFire's projection model.
Prediction: 49ers win (71.8%)

49ers vs Lions Betting Trends

- San Francisco is 10-1 straight up in its last 11 games against Detroit.
- Detroit is 1-11 straight up in its last 12 home games.
- The total has hit the under in six of San Francisco's last nine home games against Detroit.
- The total has hit the under in four of Detroit's last five games against NFC West opponents.


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Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.

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