Colts vs Bills Prediction, Odds, Spread, Over/Under & Betting Trends for NFL Week 11 Game on FanDuel

Devon Platana
Indianapolis Colts vs Buffalo Bills prediction, odds, spread, over/under and betting trends for NFL Week 11 game.
Indianapolis Colts vs Buffalo Bills prediction, odds, spread, over/under and betting trends for NFL Week 11 game. / Douglas P. DeFelice/GettyImages
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Colts vs Bills Week 11 Game Info

NFL Regular Season — Week 11 Game
Indianapolis Colts (5-5, 2-2 Away) vs. Buffalo Bills (6-3, 3-1 Home)
Date: Sunday, November 21, 2021
Time: 1:00 p.m. EST
Venue: Highmark Stadium — Orchard Park, NY
Coverage: CBS

Colts vs Bills Odds & Spread

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: IND: (+260) | BUF: (-320)
Spread: IND: +7 (-108) | BUF: -7 (-112)
Total: 49.5 — Over: (-110) | Under: (-110)
Odds to Win Super Bowl LVI: IND: (+100000) | BUF: (+4500)

Colts vs Bills Prediction & Pick

All NFL predictions and picks are from numberFire's projection model.
Prediction: Buffalo Bills win (70.4%)

Colts vs Bills Betting Trends

- Indianapolis is 5-2 against the spread (ATS) in its last seven games.
- Buffalo is 14-5-1 ATS in its last 20 games.
- The total has hit the under in seven of Indianapolis' last 10 games against Buffalo.
- The total has hit the under in six of Buffalo's last nine games as the favorite.


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Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.

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