Clemson vs Iowa State Point Spread, Over/Under, Moneyline & Prediction for College Football Cheez-It Bowl
By Larry Rupp

NCAA college football's 2021 bowl season includes a Cheez-It Bowl showdown between the Clemson Tigers and Iowa State Cyclones.
Here's everything you need to know before placing your bet for this game on FanDuel Sportsbook.
Clemson vs Iowa State Point Spread
The Tigers are 1-point favorites against the Cyclones. Clemson is -115 to cover the spread, while Iowa State is -105 to cover as the 1-point underdog.
Clemson vs Iowa State Over/Under
The over/under for the Clemson vs Iowa State college football matchup is set at 44, with -108 odds on the over and -112 odds on the under.
Clemson vs Iowa State Moneyline
The Tigers vs Cyclones moneyline has Clemson as a -124 favorite, while Iowa State is the +102 underdog.
Clemson vs Iowa State Betting Trends
- This is the first-ever head-to-head matchup between Clemson and Iowa State.
- Clemson is 5-0 straight up in its last five games.
- Iowa State is 2-4 against the spread (ATS) in its last six games.
- The total has hit the over in four of Clemson's last five games.
- The total has hit the over in six of Iowa State's last nine games.
Clemson vs Iowa State Prediction
All NCAAF predictions & expert picks are according to numberFire.
Prediction: Iowa State Cyclones win (57.0%)
Clemson vs Iowa State Odds
All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.
Moneyline: CLEM: (-124) | ISU: (+102)
Spread: CLEM: -1 (-115) | ISU: +1 (-105)
Total: 44 – Over: (-108) | Under: (-112)
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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.