And FanDuel Sportsbook has wasted no time releasing early Week 1 odds for many of these games.
The week's marquee game is the Thursday Night Football season opener, which features the Super Bowl champion Tampa Bay Buccaneers hosting the Dallas Cowboys.
Buccaneers vs Cowboys Opening Odds
FanDuel Sportsbook has the Buccaneers as 6-point favorites over the Cowboys. The Bucs' moneyline is sitting at -260, compared to the underdog Cowboys' +215.
The Bucs return the entire starting lineup from last year's Super Bowl team, which ranked fourth in the NFL with a +137 point differential in the regular season.
The Cowboys struggled mightily in 2020, with a 6-10 regular season record and the eighth-lowest point differential (-78).
Of course, that was without franchise quarterback Dak Prescott, who will be under center against Tampa. The Cowboys also made a big effort to shore up their defense, which allowed the fifth-most points in the NFL, particularly in the NFL Draft.
There's plenty of time for these odds to move before September rolls around, but the early signs are that oddsmakers are expecting a pretty one-sided game in the season opener.
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Jason Schandl is not a FanDuel employee. In addition to providing DFS gameplay advice, Jason Schandl also participates in DFS contests on FanDuel using his personal account, username Jaymun. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.