NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 3

The NFL slate in Week 3, which includes the Detroit Lions taking on the Baltimore Ravens, is sure to please.

Here is everything you need to know in terms of the betting odds for Week 3 in the NFL.

Bills vs. Dolphins

When the Buffalo Bills (2-0) and the Miami Dolphins (0-2) match up on Thursday, Sept. 18 at 8:15 p.m. ET, the Bills will be aiming to follow up their recent victory over the Jets with another win, and the Dolphins will be attempting to rebound from a loss to the Patriots.

• Game Preview: Miami Dolphins at Buffalo Bills
• Projected Favorite: Bills (79.64% win probability)
• Spread: Buffalo (-11.5)
• Total: 50.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Buffalo vs. Miami with FanDuel Sportsbook.

Vikings vs. Bengals

The Minnesota Vikings (1-1), who lost to the Falcons in their last tilt, host the Cincinnati Bengals (2-0) at U.S. Bank Stadium on Sept. 21 at 1 p.m. ET. The Bengals took home the win against the Jaguars in their last game.

• Game Preview: Cincinnati Bengals at Minnesota Vikings
• Projected Favorite: Vikings (67.72% win probability)
• Spread: Minnesota (-3)
• Total: 42.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Minnesota vs. Cincinnati with FanDuel Sportsbook.

Titans vs. Colts

The Indianapolis Colts (2-0) are set to match up with the Tennessee Titans (0-2) at Nissan Stadium on Sunday, Sept. 21 at 1 p.m. ET. In their previous games, the Colts took down the Broncos 29-28, and the Titans lost 33-19 to the Rams.

• Game Preview: Indianapolis Colts at Tennessee Titans
• Projected Favorite: Colts (60.67% win probability)
• Spread: Indianapolis (-5.5)
• Total: 43.5 -- Over: (-106) | Under: (-114)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tennessee vs. Indianapolis with FanDuel Sportsbook.

Buccaneers vs. Jets

On Sunday at 1 p.m. ET, the New York Jets (0-2) will visit the Tampa Bay Buccaneers (2-0).

• Game Preview: New York Jets at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (75.77% win probability)
• Spread: Tampa Bay (-6.5)
• Total: 43.5 -- Over: (-108) | Under: (-112)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Tampa Bay vs. New York with FanDuel Sportsbook.

Patriots vs. Steelers

At 1 p.m. ET on Sunday, the New England Patriots (1-1) are at home against the Pittsburgh Steelers (1-1).

• Game Preview: Pittsburgh Steelers at New England Patriots
• Projected Favorite: Steelers (52.13% win probability)
• Spread: Pittsburgh (-1.5)
• Total: 44.5 -- Over: (-106) | Under: (-114)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New England vs. Pittsburgh with FanDuel Sportsbook.

Eagles vs. Rams

The Philadelphia Eagles (2-0) host the Los Angeles Rams (2-0) on Sunday at 1 p.m. ET, in a matchup between a pair of the top offensive players in football in Saquon Barkley and Puka Nacua.

• Game Preview: Los Angeles Rams at Philadelphia Eagles
• Projected Favorite: Eagles (72.04% win probability)
• Spread: Philadelphia (-3.5)
• Total: 44.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. Los Angeles with FanDuel Sportsbook.

Commanders vs. Raiders

Deebo Samuel and the Washington Commanders (1-1) face the Las Vegas Raiders (1-1) on Sunday at 1 p.m. ET, at Northwest Stadium.

• Game Preview: Las Vegas Raiders at Washington Commanders
• Projected Favorite: Commanders (78.89% win probability)
• Spread: Washington (-3)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Washington vs. Las Vegas with FanDuel Sportsbook.

Browns vs. Packers

One of the best pass-catchers in football will be on display when Tucker Kraft and the Green Bay Packers (2-0) visit the Cleveland Browns (0-2) on Sunday, September 21, 2025.

• Game Preview: Green Bay Packers at Cleveland Browns
• Projected Favorite: Packers (70.45% win probability)
• Spread: Green Bay (-7.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Cleveland vs. Green Bay with FanDuel Sportsbook.

Jaguars vs. Texans

Star running back Travis Etienne and the Jacksonville Jaguars (1-1) play the Houston Texans (0-2) on Sunday at 1 p.m. ET at EverBank Stadium.

• Game Preview: Houston Texans at Jacksonville Jaguars
• Projected Favorite: Texans (51.07% win probability)
• Spread: Jacksonville (-1.5)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Jacksonville vs. Houston with FanDuel Sportsbook.

Panthers vs. Falcons

Bijan Robinson will lead the Atlanta Falcons (1-1) into their matchup versus the Carolina Panthers (0-2) at Bank of America Stadium on Sunday at 1 p.m. ET.

• Game Preview: Atlanta Falcons at Carolina Panthers
• Projected Favorite: Falcons (70.55% win probability)
• Spread: Atlanta (-4.5)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Atlanta with FanDuel Sportsbook.

Chargers vs. Broncos

One of the top pass-catchers in football will be on show when Quentin Johnston and the Los Angeles Chargers (2-0) host the Denver Broncos (1-1) on Sunday, September 21, 2025.

• Game Preview: Denver Broncos at Los Angeles Chargers
• Projected Favorite: Chargers (64.05% win probability)
• Spread: Los Angeles (-3)
• Total: 45.5 -- Over: (-110) | Under: (-110)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Los Angeles vs. Denver with FanDuel Sportsbook.

Seahawks vs. Saints

On Sunday, Sept. 21 at 4:05 p.m. ET, the Seattle Seahawks (1-1) will aim to build upon their recent 31-17 victory over the Steelers when they take on the New Orleans Saints (0-2) at Lumen Field. The Saints lost their last contest 26-21 to the 49ers.

• Game Preview: New Orleans Saints at Seattle Seahawks
• Projected Favorite: Seahawks (65.06% win probability)
• Spread: Seattle (-7.5)
• Total: 41.5 -- Over: (-108) | Under: (-112)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Seattle vs. New Orleans with FanDuel Sportsbook.

Bears vs. Cowboys

A pair of the best offensive players in football will be on display when running back Javonte Williams and the Dallas Cowboys (1-1) visit Rome Odunze and the Chicago Bears (0-2) on Sunday, September 21, 2025.

• Game Preview: Dallas Cowboys at Chicago Bears
• Projected Favorite: Bears (52.54% win probability)
• Spread: Dallas (-1.5)
• Total: 50.5 -- Over: (-104) | Under: (-118)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Chicago vs. Dallas with FanDuel Sportsbook.

49ers vs. Cardinals

Two of the top offensive players in football will be featured when running back Christian McCaffrey and the San Francisco 49ers (2-0) host Trey McBride and the Arizona Cardinals (2-0) on Sunday, September 21, 2025.

• Game Preview: Arizona Cardinals at San Francisco 49ers
• Projected Favorite: 49ers (50.93% win probability)
• Spread: San Francisco (-1.5)
• Total: 44.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on San Francisco vs. Arizona with FanDuel Sportsbook.

Giants vs. Chiefs

The Kansas City Chiefs (0-2) and the New York Giants (0-2), who were both defeated in their last game, will play at 8:20 p.m. ET on Sunday, Sept. 21. In their previous games, the Chiefs lost 20-17 to the Eagles, and the Giants were defeated by the Cowboys 40-37.

• Game Preview: Kansas City Chiefs at New York Giants
• Projected Favorite: Chiefs (65.52% win probability)
• Spread: Kansas City (-5.5)
• Total: 44.5 -- Over: (-110) | Under: (-110)
• Time: 8:20 p.m. ET
• Channel: NBC

Bet on New York vs. Kansas City with FanDuel Sportsbook.

Ravens vs. Lions

When the Baltimore Ravens (1-1) and the Detroit Lions (1-1) match up on Monday, Sept. 22 at 8:15 p.m. ET, they will both be aiming to build momentum after winning their previous contest. The Ravens won 41-17 against the Browns, and the Lions are coming off a 52-21 victory over the Bears.

• Game Preview: Detroit Lions at Baltimore Ravens
• Projected Favorite: Ravens (68.24% win probability)
• Spread: Baltimore (-5.5)
• Total: 53.5 -- Over: (-105) | Under: (-115)
• Time: 8:15 p.m. ET
• Channel: ABC/ESPN

Bet on Baltimore vs. Detroit with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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