Clemson vs Syracuse Prediction, Odds, Picks, Best Bets for Week 4 2025

The Clemson Tigers will take on the Syracuse Orange in college football action on Saturday.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Clemson vs Syracuse Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Clemson: (-847) | Syracuse: (+570)
• Spread: Clemson: -17.5 (-110) | Syracuse: +17.5 (-110)
• Total: 55.5 -- Over: (-105) | Under: (-115)

Clemson vs Syracuse Betting Trends

• Clemson is winless against the spread this season.
• Clemson has no wins ATS (0-1) as a 17.5-point favorite or greater this year.
• Not one of Clemson's three games has hit the over in 2025.
• Syracuse has one win against the spread this year.
• Syracuse has played two games (out of three) which finished over the total this year.

Clemson vs Syracuse Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (80.4%)

Clemson vs Syracuse Point Spread

Clemson is favored by 17.5 points versus Syracuse. Clemson is -110 to cover the spread, while Syracuse is -110.

Clemson vs Syracuse Over/Under

A combined point total of 55.5 has been set for Clemson-Syracuse on Sept. 20, with the over at -105 and the under at -115.

Clemson vs Syracuse Moneyline

The Clemson vs Syracuse moneyline has Clemson as a -847 favorite, while Syracuse is a +570 underdog.

Clemson vs. Syracuse Points Insights

Clemson vs. Syracuse Game Info

• Game day: Saturday, September 20, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN
• Location: Clemson, South Carolina
• Stadium: Memorial Stadium (Clemson, SC)

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Check out even more in-depth Clemson vs. Syracuse analysis on FanDuel Research.