Clemson vs Syracuse Prediction, Odds, Picks, Best Bets for Week 4 2025

College football's Saturday slate includes the Clemson Tigers facing the Syracuse Orange.

We've got you covered, in terms of the most important information regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Clemson vs Syracuse Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Clemson: (-820) | Syracuse: (+550)
• Spread: Clemson: -16.5 (-115) | Syracuse: +16.5 (-105)
• Total: 54.5 -- Over: (-108) | Under: (-112)

Clemson vs Syracuse Betting Trends

• Clemson has no wins against the spread this season.
• Clemson has yet to win ATS (0-1) when playing as at least 16.5-point favorites this season.
• Clemson has yet to hit the over this season.
• Syracuse has posted one win against the spread this year.
• Two Syracuse games (of three) have gone over the point total this season.

Clemson vs Syracuse Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Tigers win (79.6%)

Clemson vs Syracuse Point Spread

Clemson is favored by 16.5 points (-115 to cover) in this matchup. Syracuse, the underdog, is -105.

Clemson vs Syracuse Over/Under

An over/under of 54.5 has been set for Clemson-Syracuse on Sept. 20, with the over being -108 and the under -112.

Clemson vs Syracuse Moneyline

Syracuse is the underdog, +550 on the moneyline, while Clemson is a -820 favorite.

Clemson vs. Syracuse Points Insights

Clemson vs. Syracuse Game Info

• Game day: Saturday, September 20, 2025
• Game time: 12 p.m. ET
• TV channel: ESPN
• Location: Clemson, South Carolina
• Stadium: Memorial Stadium (Clemson, SC)

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Check out even more in-depth Clemson vs. Syracuse analysis on FanDuel Research.