49ers vs Cardinals Prediction, Odds, Picks, Best Bets for NFL Week 3

NFL action on Sunday includes the San Francisco 49ers taking on the Arizona Cardinals.

Before you place your bet on this game at FanDuel Sportsbook, here are the NFL moneyline insights you need to know.

49ers vs Cardinals Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: 49ers win (51.3%)

49ers vs Cardinals Point Spread

The 49ers are 2.5-point favorites against the Cardinals. The 49ers are -105 to cover the spread, while the Cardinals are -115 to cover as a 2.5-point underdog.

49ers vs Cardinals Over/Under

A combined point total of 44.5 has been set for 49ers-Cardinals on Sept. 21, with the over at -114 and the under at -106.

49ers vs Cardinals Moneyline

Arizona is a +114 underdog on the moneyline, while San Francisco is a -134 favorite on the road.

49ers vs Cardinals Betting Trends

• San Francisco has covered the spread in every game this season.
• The 49ers have covered every time (1-0) as a 2.5-point favorite or greater this season.
• One of the 49ers' two games this season has gone over the point total.
• The Cardinals have won once against the spread this season.
• The Cardinals have had one game (out of two) go over the total this season.

Check out even more in-depth 49ers vs. Cardinals analysis on FanDuel Research.

49ers vs Cardinals Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-134) | ARI: (+114)
• Spread: SF: -2.5 (-105) | ARI: +2.5 (-115)
• Total: 44.5 -- Over: (-114) | Under: (-106)

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