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Steelers vs Bills Spread, Odds, Line, Over/Under, Prediction and Betting Insights for NFL Week 1 Game

Larry Rupp
Pittsburgh Steelers vs Buffalo Bills prediction, odds, over, under, spread and prop bets for Week 1 NFL game.
Pittsburgh Steelers vs Buffalo Bills prediction, odds, over, under, spread and prop bets for Week 1 NFL game. / Adam Glanzman/Getty Images
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Steelers vs Bills Week 1 Game Info

NFL Week 1 Game
Pittsburgh Steelers (0-0, 0-0 Away) vs. Buffalo Bills (0-0, 0-0 Home)
Date: Sunday, Sep. 12, 2021
Time: 1 p.m. EST
Venue: Highmark Stadium — Orchard Park, NY
Coverage: CBS

Steelers vs Bills Spread & Odds

All NFL betting lines, odds, and prop bets are available on FanDuel Sportsbook.
Moneyline: PIT: (+225) | BUF: (-275)
Spread: PIT: +6.5 (-110) | BUF: -6.5 (-110)
Total: N/A – Over: (N/A) | Under: (N/A)
Public (Spread) Betting Percentages via oddsFire: PIT: (N/A) | BUF: (N/A)
Odds to Win Super Bowl LV: PIT: (+4400) | BUF: (+1200)

Steelers vs Bills Expert Prediction & Pick

All Steelers-Bills expert predictions and picks will be updated when available.

Steelers vs Bills Betting Trends

- Pittsburgh went 10-7 against the spread (ATS) last season.
- The total hit the over in eight of Pittsburgh's 17 games last season.
- Buffalo went 12-7 ATS last season.
- The total hit the over in 12 of Buffalo's 19 games last season.

Steelers vs Bills Stats

- Pittsburgh averaged 26.6 points per game (PPG) last season (No. 12 in the NFL).
- Pittsburgh surrendered 21.2 PPG last season (T-No. 5 in the NFL).
- Buffalo averaged 29.9 PPG last season (No. 3 in the NFL).
- Buffalo surrendered 23.2 PPG last season (T-No. 14 in the NFL).


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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

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