NFL Week 1 Odds for Games With Largest Spreads and Over/Under

Dan Israeli
Divisional Round - Indianapolis Colts v Kansas City Chiefs
Divisional Round - Indianapolis Colts v Kansas City Chiefs / Jamie Squire/Getty Images

Week 1 of the NFL season is quickly approaching as it's set to kick off Sept. 5 with Thursday Night Football when the Chicago Bears host the Green Bay Packers.

A full slate of games will follow on Sunday, Sept. 8, with many intriguing matchups on the docket in Week 1. However, the most lopsided projection, according to Fanduel Sportsbook, is between the Cincinnati Bengals and Seattle Seahawks, which kicks off at 4:05 p.m. EST at CenturyLink Field in Seattle. The Seahawks are favored by 10 points over the visiting Bengals.

The Seahawks are coming off a 10-6 season, in which they went 6-2 straight up at home, and 5-2-1 against the spread (ATS). The Bengals, meanwhile, disappointed in 2018 with a 6-10 record. They were 2-6 straight up on the road, but 6-2 ATS in those games.

Still, the Bengals are at a major disadvantage to start the year without their top wide receiver, and arguably best overall player in A.J. Green. Seattle is already a tough place to play, and the crowd should be smelling blood for a Week 1 matchup against a team with very low expectations in 2019. The Bengals have a projected win total of just six games this season, compared to the Seahawks' 8.5-win projection.

The game with the highest over/under total in Week 1, according to FanDuel Sportsbook, is the Houston Texans at the New Orleans Saints, which has been set at 53.5 points. This potential shootout features the league's third and 11th highest-scoring teams from last season.

While the Texans were dealt a big blow in Week 3 of the preseason, losing starting RB Lamar Miller to a torn ACL, they were wise to add Duke Johnson Jr. via trade earlier in training camp. The Texans may still add another RB before Week 1, but they have plenty of firepower with Deshaun Watson at quarterback, along with the wide receiver trio of DeAndre Hopkins, Will Fuller V and Keke Coutee.

The Saints, meanwhile, will once again be led by QB Drew Brees, who has one of the league's most explosive running backs in Alvin Kamara and one of the league's most reliable wide receivers in Michael Thomas at his disposal.

The Saints also added RB Latavius Murray and TE Jared Cook in free agency, adding to what should be one of the NFL's most potent offensive attacks once again this season. We could have a shootout on the horizon in Week 1 at the Superdome.

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