NCAAF Betting

Louisville vs Duke Prediction, Odds, Spread, Date & Start Time for College Football Week 12 Game

Devon Platana
Louisville vs Duke prediction, odds, spread, date & start time for college football Week 12 game.
Louisville vs Duke prediction, odds, spread, date & start time for college football Week 12 game. / Grant Halverson/GettyImages
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Louisville vs Duke Week 12 Game Info

Week 12 College Football Game
Louisville Cardinals (5-5, 3-4 ACC) vs. Duke Blue Devils (3-7, 0-6 ACC)
Date: Thursday, November 18, 2021
Time: 7:30 p.m. EST
Venue: Wallace Wade Stadium – Durham, NC
Coverage: ESPN

Louisville vs Duke Spread & Odds

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.
Moneyline: LOU: (-1250) | DUKE: (+710)
Spread: LOU: -19.5 (-115) | DUKE: +19.5 (-105)
Total: 60.5 – Over: (-110) | Under: (-110)

Louisville vs Duke Prediction & Pick

All NCAAF predictions & expert picks are according to numberFire.
Prediction: Louisville wins (98.6%)

Louisville vs Duke Head-to-Head Record & Betting Trends

- Louisville is 2-0 in two all-time head-to-head matchups against Duke.
- Louisville defeated Duke, 24-14, in their last meeting on Oct. 14, 2016.
- The total has hit the under in four of Louisville's last five games against ACC opponents.
- The total has hit the under in four of Duke's last six games this season.
- Louisville is 1-8 straight up in its last nine road games.
- Duke is 1-5 against the spread (ATS) in its last six games.


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Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.

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