The Duel

Cardinals-49ers Predictions and Expert Picks for NFL Week 1 Game

Max Staley
Expert predictions for the NFL Week 1 Cardinals-49ers matchup.
Expert predictions for the NFL Week 1 Cardinals-49ers matchup. / Lachlan Cunningham/Getty Images

The Arizona Cardinals and San Francisco 49ers will face off in Week 1 in an exciting clash between two NFC West teams.

Here's how the experts are predicting this game to play out.

Cardinals vs 49ers Picks Week 1

CBS Sports picks are from their panel of experts, numberFire picks are from their NFL game projections, Sporting News picks are from Vinnie Iyer, and betting favorites are from FanDuel Sportsbook's Week 1 NFL odds.

CBS Sports: 49ers (6)
numberFire: 49ers
Sporting News: 49ers
Betting Favorite: 49ers

Against the Spread:
CBS Sports: Cardinals (6)
Sporting News: Cardinals

All nine experts we highlighted above like San Francisco to win straight up. However, all seven that made an ATS pick are rolling with Arizona, suggesting the Cardinals should be able to at least keep this one close.

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Max Staley is not a FanDuel employee. In addition to providing DFS gameplay advice, Max Staley also participates in DFS contests on FanDuel using his personal account, username mstaley1212. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.