NFL Week 1 Picks & Predictions Against the Spread From The Duel Staff

The 2021 NFL is set to kick off on Thursday with the Dallas Cowboys vs the Tampa Bay Buccaneers, and the editors at The Duel are making against the spread (ATS) picks for each game. You can follow along, check it out, or fade us throughout the season.

NFL Week 1 Predictions

We have full betting previews for each matchup below along with the betting lines from FanDuel Sportsbook. We’ll update this with records on a weekly basis and make picks for every round of the playoffs through the Super Bowl.

Without further ado, here are our picks.

NFL Expert Picks Against the Spread

Note: All betting lines and odds are from FanDuel Sportsbook, as of Tuesday, Sept. 7 at 4 p.m. EST.

Cowboys vs Buccaneers Picks

Cowboys (+7.5) vs Buccaneers (-7.5) Betting Preview

Staff Picks (ATS):
- Taylor McKillop: Cowboys
- David Kaestle: Buccaneers
- Isaiah De Los Santos: Buccaneers
- Jason Schandl: Cowboys
- Max Staley: Buccaneers

Steelers vs Bills Picks

Steelers (+6.5) vs Bills (-6.5) Betting Preview

Staff Picks (ATS):
- Taylor McKillop: Bills
- David Kaestle: Steelers
- Isaiah De Los Santos: Bills
- Jason Schandl: Steelers
- Max Staley: Bills

Jets vs Panthers Picks

Jets (+5) vs Panthers (-5) Betting Preview

Staff Picks (ATS):
- Taylor McKillop: Panthers
- David Kaestle: Jets
- Isaiah De Los Santos: Panthers
- Jason Schandl: Jets
- Max Staley: Jets

Jaguars vs Texans Picks

Jaguars (-2.5) vs Texans (+2.5) Betting Preview

Staff Picks (ATS):
- Taylor McKillop: Jaguars
- David Kaestle: Jaguars
- Isaiah De Los Santos: Jaguars
- Jason Schandl: Texans
- Max Staley: Jaguars

Cardinals vs Titans Picks

Cardinals (+3) vs Titans (-3) Betting Preview

Staff Picks (ATS):
- Taylor McKillop: Titans
- David Kaestle: Cardinals
- Isaiah De Los Santos: Cardinals
- Jason Schandl: Cardinals
- Max Staley: Titans

Eagles vs Falcons Picks

Eagles (+3.5) vs Falcons (-3.5) Betting Preview

Staff Picks (ATS):
- Taylor McKillop: Eagles
- David Kaestle: Falcons
- Isaiah De Los Santos: Falcons
- Jason Schandl: Eagles
- Max Staley: Eagles

Chargers vs Washington Picks

Chargers (-1) vs Washington (+1) Betting Preview

Staff Picks (ATS):
- Taylor McKillop: Washington
- David Kaestle: Washington
- Isaiah De Los Santos: Washington
- Jason Schandl: Chargers
- Max Staley: Chargers

49ers vs Lions Picks

49ers (-7.5) vs Lions (+7.5) Betting Preview

Staff Picks (ATS):
- Taylor McKillop: 49ers
- David Kaestle: 49ers
- Isaiah De Los Santos: 49ers
- Jason Schandl: Lions
- Max Staley: 49ers

Seahawks vs Colts Picks

Seahawks (-2.5) vs Colts (+2.5) Betting Preview

Staff Picks (ATS):
- Taylor McKillop: Colts
- David Kaestle: Seahawks
- Isaiah De Los Santos: Colts
- Jason Schandl: Seahawks
- Max Staley: Colts

Vikings vs Bengals Picks

Vikings (-3) vs Bengals (+3) Betting Preview

Staff Picks (ATS):
- Taylor McKillop: Bengals
- David Kaestle: Vikings
- Isaiah De Los Santos: Vikings
- Jason Schandl: Vikings
- Max Staley: Bengals

Dolphins vs Patriots Picks

Dolphins (+3) vs Patriots (-3) Betting Preview

Staff Picks (ATS):
- Taylor McKillop: Patriots
- David Kaestle: Dolphins
- Isaiah De Los Santos: Dolphins
- Jason Schandl: Patriots
- Max Staley: Patriots

Browns vs Chiefs Picks

Browns (+6.5) vs Chiefs (-6.5) Betting Preview

Staff Picks (ATS):
- Taylor McKillop: Chiefs
- David Kaestle: Chiefs
- Isaiah De Los Santos: Browns
- Jason Schandl: Chiefs
- Max Staley: Browns

Broncos vs Giants Picks

Broncos (-2.5) vs Giants (+2.5) Betting Preview

Staff Picks (ATS):
- Taylor McKillop: Broncos
- David Kaestle: Giants
- Isaiah De Los Santos: Broncos
- Jason Schandl: Giants
- Max Staley: Broncos

Packers vs Saints Picks

Packers (-4) vs Saints (+4) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: 
- Taylor McKillop: Packers
- David Kaestle: Packers
- Isaiah De Los Santos: Packers
- Jason Schandl: Saints
- Max Staley: Saints

Bears vs Rams Picks

Bears (+7.5) vs Rams (-7.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: 
- Taylor McKillop: Rams
- David Kaestle: Rams
- Isaiah De Los Santos: Rams
- Jason Schandl: Bears
- Max Staley: Rams

Ravens vs Raiders Picks

Ravens (-4.5) vs Raiders (+4.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: 
- Taylor McKillop: Ravens
- David Kaestle: Ravens
- Isaiah De Los Santos: Raiders
- Jason Schandl: Raiders
- Max Staley: Raiders

Staff Records (ATS):
- Brian Giuffra: 0-0
- Taylor McKillop: 0-0
- David Kaestle: 0-0
- Isaiah De Los Santos: 0-0
- Jason Schandl: 0-0
- Max Staley: 0-0

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David Kaestle is not a FanDuel employee. In addition to providing DFS gameplay advice, David also participates in DFS contests on FanDuel using his personal account, username davekaestle. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.