Bills vs Patriots Prediction, Odds, Spread, Over/Under & Betting Trends for NFL Week 16 Game on FanDuel Sportsbook

Larry Rupp
Buffalo Bills vs New England Patriots prediction, odds, spread, over/under and betting trends for NFL Week 16 game.
Buffalo Bills vs New England Patriots prediction, odds, spread, over/under and betting trends for NFL Week 16 game. / Bryan Bennett/GettyImages
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Bills vs Patriots Week 16 Game Info

NFL Regular Season — Week 16 Game
Buffalo Bills (8-6, 3-4 Away) vs. New England Patriots (9-5, 3-4 Home)
Date: Sunday, December 26, 2021
Time: 1:00 p.m. EST
Venue: Gillette Stadium — Foxboro, MA
Coverage: CBS

Bills vs Patriots Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: BUF: (+110) | NE: (-130)
Spread: BUF: +1.5 (-105) | NE: -1.5 (-115)
Total: 43.5 — Over: (-110) | Under: (-110)
Odds to Win Super Bowl LVI: BUF: (+1100) | NE: (+1100)

Bills vs Patriots Prediction & Pick

All NFL predictions and picks are from numberFire's projection model and will be updated when available.
Prediction: New England Patriots win (63.2%)

Bills vs Patriots Betting Trends

- Buffalo is 4-16 straight up in its last 20 games against New England.
- The total has hit the over in four of Buffalo's last six games.
- New England is 7-1 against the spread (ATS) in its last eight games.
- The total has hit the over in four of New England's last five home games.


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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

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