NFL - Odds & Predictions

49ers vs Lions Point Spread, Over/Under, Moneyline and Betting Trends for NFL Week 1 Game Today

Jason Schandl
San Francisco 49ers vs Detroit Lions odds, point spread, moneyline, over/under and betting trends for NFL Week 1 Game.
San Francisco 49ers vs Detroit Lions odds, point spread, moneyline, over/under and betting trends for NFL Week 1 Game. / Nic Antaya/Getty Images
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Today's Week 1 slate of 1 p.m. games includes a showdown between the San Francisco 49ers and Detroit Lions.

Here's everything you need to know before placing your bet for this game on FanDuel Sportsbook.

49ers vs Lions Point Spread

The 49ers are 8.5-point road favorites against the Lions. San Francisco is -110 to cover the spread, while the Lions are -110 to cover as 8.5-point underdogs.

49ers vs Lions Over/Under

The over/under for the 49ers vs Lions Week 1 NFL matchup is set at 45.5 , with -115 odds on the over and -105 odds on the under.

49ers vs Lions Moneyline

The 49ers vs Lions moneyline has San Francisco as a -420 favorite, while the Lions are +330 underdogs at home.

49ers vs Lions Betting Trends

- San Francisco is 10-1 straight up in its last 11 games against Detroit.
- Detroit is 1-11 straight up in its last 12 home games.
- The total has hit the under in six of San Francisco's last nine home games against Detroit.
- The total has hit the under in four of Detroit's last five games against NFC West opponents.

49ers vs Lions Odds

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (-420) | DET: (+330)
Spread: SF: -8.5 (-110) | DET: +8.5 (-110)
Total: 45.5 — Over: (-115) | Under: (-105)
Public (Spread) Betting Percentages via oddsFire: SF: (55%) | DET: (45%)
Odds to Win Super Bowl LVI: SF: (+1300) | DET: (+20000)


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Jason Schandl is not a FanDuel employee. In addition to providing DFS gameplay advice, Jason Schandl also participates in DFS contests on FanDuel using his personal account, username Jaymun. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.

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