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Week 6 Fantasy Picks: Start 'Em, Sit 'Em for Cardinals vs Browns

Larry Rupp
Fantasy football picks for the Arizona Cardinals vs Cleveland Browns Week 6 matchup, including Kyler Murray, Odell Beckham Jr. and James Conner.
Fantasy football picks for the Arizona Cardinals vs Cleveland Browns Week 6 matchup, including Kyler Murray, Odell Beckham Jr. and James Conner. / Norm Hall/GettyImages
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The Arizona Cardinals will look to stay unbeaten on the season when they go on the road to take on the Cleveland Browns in Week 6 NFL action. FanDuel Sportsbook has the Browns slated as 3-point favorites in a game that is full of playmakers on both sides of the football.

If you need some help with your fantasy lineups, here's some start 'em, sit 'em advice for this exciting Week 6 showdown.

Kyler Murray Fantasy

Start Kyler Murray, QB, Arizona Cardinals: Kyler Murray is an early MVP candidate as he leads the NFL with a 75.2% completion percentage and has accounted for 13 total touchdowns on the season. He draws a great matchup in Week 6 going up against a Cleveland defense that is giving up the fourth-most fantasy points to opposing QBs in 2021. The Browns have also already allowed 3 rushing touchdowns to the position, which is tied for the second-highest mark in the NFL. Look for Murray to use his legs in order to put together another big performance on Sunday.

Odell Beckham Jr. Fantasy

Start Odell Beckham Jr., WR, Cleveland Browns: The Browns put up 535 yards of offense in Week 5, yet Odell Beckham Jr. had just 20 yards on 2 catches. The good news is that the Browns' No. 1 option played in a season-high 81% of the offensive snaps and is averaging 6.3 targets per game. The volume is there, and he has a chance to bounce back in Week 6 given the Cardinals have allowed 7 touchdowns to opposing WRs this season (T-No. 23 in NFL). Beckham is a viable FLEX option this week and an underrated target in the daily fantasy market.

James Conner Fantasy

Sit James Conner, RB, Arizona Cardinals: James Conner scored a whopping 5 rushing touchdowns and ranks as the RB14 in PPR scoring over the last three weeks. He has yet to out-snap starter Chase Edmonds in any game this season, however. Edmonds is averaging 5.5 yards per carry, which is lightyears ahead of the 3.2 mark posted by Conner so far. Conner will also face a unit that's posted the fifth-best rush defense DVOA rating and giving up the fifth-fewest PPR fantasy points to the position. All of this adds up to Conner staying on the bench this week.

David Njoku Fantasy

Sit David Njoku, TE, Cleveland Browns: Tight end David Njoku came out of nowhere in Week 5, hauling in all 7 of his targets for 149 yards and 1 touchdown. That doesn't mean he has become an automatic start in fantasy football, though. Njoku has yet to play in over 67% of the offensive snaps in any game this season, which means he's a boom-or-bust option in the limited time he is on the field. The Cardinals also have been superb at defending tight ends this season and are allowing the second-fewest PPR fantasy points to the position. Njoku is a great bench stash, but that is all for right now.


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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

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