Week 10 NFL Odds and Lines Have Saints Facing Largest Spread and Cardinals vs Bucs as Highest Total

Zach Brunner

With six teams on bye in Week 10, there are only 13 games on this week's slate. And of those 13, there are three games with a double-digit point spread, according to FanDuel Sportsbook.

NFL Odds This Week

Looking at the totals for Week 10, the game with the highest over/under belongs to the matchup between the Tampa Bay Buccaneers and Arizona Cardinals.

It's the second straight week Tampa Bay has been a part of the game with the highest over/under total. In this one, the over/under is set at 52.5, after the Buccaneers and Seattle Seahawks scored a combined 74 points in Week 9.

On the other end, the matchup between the Buffalo Bills and Cleveland Browns features the lowest over/under of the week, at 41.5. This is also the second straight week the Bills have played in the game with the lowest over/under total.

The largest spread of the week comes in a battle between two teams in the NFC South, with the New Orleans Saints being favored by 12 points at home over the Atlanta Falcons.

The smallest spread, meanwhile, belongs to the first game of Week 10, with the Los Angeles Chargers being listed as 1-point road favorites over the Oakland Raiders on "Thursday Night Football."

Join FanDuel Sportsbook Today. New users get a risk-free bet up to $500. Join Now.