Tigers vs Guardians Prediction, Odds, Probable Pitchers, Betting Lines & Spread for MLB Game on FanDuel (May 22)
By Larry Rupp

Tigers vs Guardians Game Info
2022 MLB Regular Season Game
Detroit Tigers (13-26, 4-13 Away) vs. Cleveland Guardians (17-19, 8-7 Home)
Date: Sunday, May 22, 2022
Time: 1:40 p.m. ET
Venue: Progressive Field — Cleveland, OH
Tigers vs Guardians Odds & Spread
All MLB odds, totals and spreads are according to FanDuel Sportsbook.
Moneyline: DET: (+160) | CLE: (-190)
Spread: DET: +1.5 (-140) | CLE: -1.5 (+116)
Total: 7 – Over: (-115) | Under: (-105)
World Series Odds: DET: (+25000) | CLE: (+8000)
Tigers vs Guardians Probable Pitchers
Tigers: Alex Faedo (0-1, 2.87 ERA)
Guardians: Shane Bieber (1-2, 3.72 ERA)
Tigers vs Guardians Prediction & Pick
All MLB predictions & expert picks are according to numberFire.
Prediction: Cleveland Guardians win (66.1%)
Tigers vs Guardians Betting Trends
- Detroit is 3-13 straight up in its last 16 away games.
- The total has hit the under in 12 of Detroit's last 16 games.
- Cleveland is 4-1 straight up in its last five games against Cleveland.
- The total has hit the over in seven of Cleveland's last 10 home games.
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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.