Steelers vs Bills Prediction, Odds, Spread, Over/Under & Betting Trends for NFL Week 1 Game on FanDuel Sportsbook

Steelers vs Bills Game Info

NFL Regular Season — Week 1 Game
Pittsburgh Steelers (0-0, 0-0 Away) vs. Buffalo Bills (0-0, 0-0 Home)
Date: Sunday, September 12, 2021
Time: 1:00 p.m. EST
Venue: Highmark Stadium — Orchard Park, NY
Coverage: CBS

Steelers vs Bills Odds & Spread

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: PIT: (+220) | BUF: (-270)
Spread: PIT: +6.5 (-111) | BUF: -6.5 (-108)
Total: 48.5 — Over: (-104) | Under: (-118)
Public (Spread) Betting Percentages via oddsFire: PIT: (36%) | BUF: (64%)
Odds to Win Super Bowl LVI: PIT: (+4400) | BUF: (+1200)

Steelers vs Bills Prediction & Pick

All NFL predictions and picks are from numberFire's projection model.

Prediction: Bills win (74.0%)

Steelers vs Bills Betting Trends

- The total has hit the over in four of Pittsburgh's last five games.
- Buffalo is 7-0 straight up in its last seven home games.
- Pittsburgh is 10-3 against the spread (ATS) in its last 13 games against Buffalo.
- The total has hit the over in 13 of Buffalo's last 19 games.

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Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.