The Duel

Rams vs Bills Point Spread, Over/Under, Moneyline and Betting Trends for NFL Week 3

By michael obermuller
Los Angeles Rams vs Buffalo Bills Week 3 point spread, over/under, moneyline and betting trends.
Los Angeles Rams vs Buffalo Bills Week 3 point spread, over/under, moneyline and betting trends. / Michael Reaves/Getty Images
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The undefeated Los Angeles Rams will take on the undefeated Buffalo Bills at Bills Stadium in Orchard Park, New York, as Week 3 rolls along on Sunday, September 27.

Here's everything you need to know before placing your bet for this game on FanDuel Sportsbook.

Rams vs Bills Point Spread

Los Angeles is a 1.5-point underdog on the road in Week 3. Buffalo is a 1.5-point home favorite, with -115 odds on the Rams' spread compared to -105 odds on the Bills'.

Rams vs Bills Over/Under

The over/under for the Rams vs Bills Week 3 matchup is set at 47.5 total points, with -110 odds on both the over and the under.

Rams vs Bills Moneyline

The Rams vs Bills moneyline has Buffalo as a -124 favorite at home, while Los Angeles is a +106 road underdog.

Rams vs Bills Betting Trends

- The Rams are 5-1-1 against the spread (ATS) in their last seven games going back to 2019.
- The total has hit the over in four of the Rams' last five games going back to 2019.
- Buffalo is 1-4 ATS in its last five games going back to 2019.
- The total has hit the under in 13 of Buffalo's last 19 games going back to 2019.

Rams vs Bills Odds

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.
Moneyline: LAR: (+106) | BUF: (-124)
Spread: LAR: +1.5 (-110) | BUF: -1.5 (-110)
Total: 47.5 – Over: (-110) | Under: (-110)
Public (Spread) Betting Percentages via oddsFireLAR: (69%) | BUF: (31%)
Odds to Win Super Bowl LV: LAR: (+2300) | BUF: (+2200)


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Michael Obermuller is not a FanDuel employee. In addition to providing DFS gameplay advice, Michael Obermuller also participates in DFS contests on FanDuel using his personal account, username king_mizzard. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

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