Ole Miss vs Louisville Prediction, Odds, Spread, Date & Start Time for College Football Week 1 Game

Ole Miss vs Louisville Week 1 Game Info

Week 1 College Football Game
Ole Miss Rebels (0-0, 0-0 Away) vs. Louisville Cardinals (0-0, 0-0 Home)
Date: Monday, September 6, 2021
Time: 8:00 p.m. EST
Venue: Mercedes-Benz Stadium – Atlanta, GA
Coverage: ESPN

Ole Miss vs Louisville Spread & Odds

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.
Moneyline: MISS: (-385) | LOU: (+290)
Spread: MISS: -9.5 (-110) | LOU: +9.5 (-110)
Total: 75.5 – Over: (-115) | Under: (-105)
Public (Spread) Betting Percentages via oddsFire: MISS: (N/A) | LOU: (N/A)

Ole Miss vs Louisville Prediction

All NCAAF predictions & expert picks are according to ESPN's Football Power Index (FPI).
Winning Percentage Prediction: Ole Miss: (70.1%) | Louisville: (29.9%)

Ole Miss vs Louisville Head-to-Head Record & Betting Trends

- This is the first all-time head-to-head matchup between Ole Miss and Louisville.
- Ole Miss is 4-1 straight up in its last five games.
- The total has hit the over in four of Ole Miss' last five Week 1 games.
- Louisville is 1-6 straight up in its last seven games as an underdog.
- The total has hit the over in 12 of Louisville's last 16 games.

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.