NFL Week 5 ATS Matchups to Exploit

Week 4 of the NFL season brought us some of the biggest upsets of the year. A total of seven road underdogs won their matchup outright, including the Oakland Raiders and Tampa Bay Buccaneers, who were both at least 7-point underdogs.

Whether or not Week 5 will bring the same level of chaos remains to be seen, but here are five matchups to potentially exploit against the spread (ATS) this weekend.

All betting lines, odds and spreads available via FanDuel Sportsbook.

3. Arizona Cardinals (+3) vs. Cincinnati Bengals

Through four weeks, the Cincinnati Bengals have proven they have no business being favored against any team in the NFL (other than the Miami Dolphins). Cincinnati surrendered 140 yards receiving on 16 receptions to RBs in Week 4, so expect to see a hefty dose of David Johnson here. While the Arizona Cardinals haven't been much better, sitting at 0-1-3, they managed to stay competitive against superior teams in the Detroit Lions and Baltimore Ravens. Additionally, 52 of Arizona's 74 points have come in the second half thus far, which often creates the opportunity for a backdoor cover.

2. Tampa Bay Buccaneers (+3) vs. New Orleans Saints

The Tampa Bay Buccaneers have surprisingly been one of the best run defenses in the NFL, surrendering 237 rushing yards thus far, which is the lowest total in the NFL among all teams that have played four games. That could be problematic for a New Orleans Saints' offense that is extremely reliant on Alvin Kamara's running ability. When Teddy Bridgewater has been forced to throw, he's been pretty efficient, but far from dynamic. Bridgewater has yet to top 200 yards in any of his three appearances, and he could struggle if he's asked to carry this offense by himself. Meanwhile, Tampa Bay's offense is rolling, averaging 35.3 points per game (PPG) over its last three contests, including two straight performances of at least 30 points. Tampa Bay upset New Orleans on the road last season, and certainly has a chance to do the same here.

1. Cleveland Browns (+3.5) vs. San Francisco 49ers

The San Francisco 49ers have been rolling, jumping out to a 3-0 start, but with left tackle Joe Staley out for this game, Myles Garrett and the Cleveland Browns' pass rush could feast on "Monday Night Football." Garrett already has six sacks this season (No. 2 in the NFL) and the Browns have racked up 14 sacks as a team (tied for No. 4 in the NFL). Cleveland's offense looked like it finally got in a rhythm in Week 4, putting up 40 points against the Baltimore Ravens and if the defense keeps San Francisco's passing attack in check, the Browns could soon find themselves above .500 for the first time all season.

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Max Staley is not a FanDuel employee. In addition to providing DFS gameplay advice, Max Staley also participates in DFS contests on FanDuel using his personal account, username mstaley1212. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.