NFL Week 4 Picks & Predictions Against the Spread From The Duel Staff

The 2021 NFL season has gotten off to a hot start, and the editors at The Duel are making against the spread (ATS) picks for each game. You can follow along, check it out, or fade us throughout the season.

NFL Week 4 Predictions

We have full betting previews for each matchup below along with the betting lines from FanDuel Sportsbook. We’ll update this with records on a weekly basis and make picks for every round of the playoffs through the Super Bowl.

Without further ado, here are our picks.

NFL Expert Picks Against the Spread

Note: All betting lines and odds are from FanDuel Sportsbook, as of Tuesday, Sept. 28 at 4 p.m. EST.

Jaguars vs Bengals Picks

Jaguars (+7.5) vs Bengals (-7.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Bengals
- Taylor McKillop: Bengals
- David Kaestle: Bengals
- Isaiah De Los Santos: Bengals
- Jason Schandl: Jaguars
- Max Staley: Bengals

Washington vs Falcons Picks

Washington (-1.5) vs Falcons (+1.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Falcons
- Taylor McKillop: Washington
- David Kaestle: Falcons
- Isaiah De Los Santos: Falcons
- Jason Schandl: Washington
- Max Staley: Washington

Lions vs Bears Picks

Lions (+3) vs Bears (-3) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Lions
- Taylor McKillop: Lions
- David Kaestle: Lions
- Isaiah De Los Santos: Lions
- Jason Schandl: Bears
- Max Staley: Bears

Titans vs Jets Picks

Titans (-7.5) vs Jets (+7.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Titans
- Taylor McKillop: Titans
- David Kaestle: Titans
- Isaiah De Los Santos: Titans
- Jason Schandl: Jets
- Max Staley: Jets

Browns vs Vikings Picks

Browns (-2.5) vs Vikings (+2.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Vikings
- Taylor McKillop: Vikings
- David Kaestle: Vikings
- Isaiah De Los Santos: Browns
- Jason Schandl: Vikings
- Max Staley: Browns

Colts vs Dolphins Picks

Colts (+1.5) vs Dolphins (-1.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Colts
- Taylor McKillop: Dolphins
- David Kaestle: Dolphins
- Isaiah De Los Santos: Dolphins
- Jason Schandl: Colts
- Max Staley: Dolphins

Panthers vs Cowboys Picks

Panthers (+4.5) vs Cowboys (-4.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Cowboys
- Taylor McKillop: Cowboys
- David Kaestle: Cowboys
- Isaiah De Los Santos: Panthers
- Jason Schandl: Panthers
- Max Staley: Panthers

Giants vs Saints Picks

Giants (+7.5) vs Saints (-7.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Giants
- Taylor McKillop: Giants
- David Kaestle: Giants
- Isaiah De Los Santos: Saints
- Jason Schandl: Saints
- Max Staley: Giants

Chiefs vs Eagles Picks

Chiefs (-7.5) vs Eagles (+7.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Chiefs
- Taylor McKillop: Chiefs
- David Kaestle: Chiefs
- Isaiah De Los Santos: Chiefs
- Jason Schandl: Eagles
- Max Staley: Chiefs

Texans vs Bills Picks

Texans (+16.5) vs Bills (-16.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Bills
- Taylor McKillop: Texans
- David Kaestle: Bills
- Isaiah De Los Santos: Bills
- Jason Schandl: Texans
- Max Staley: Bills

Cardinals vs Rams Picks

Cardinals (+6) vs Rams (-6) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Rams
- Taylor McKillop: Rams
- David Kaestle: Rams
- Isaiah De Los Santos: Cardinals
- Jason Schandl: Cardinals
- Max Staley: Cardinals

Seahawks vs 49ers Picks

Seahawks (+3) vs 49ers (-3) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Seahawks
- Taylor McKillop: Seahawks
- David Kaestle: Seahawks
- Isaiah De Los Santos: 49ers
- Jason Schandl: 49ers
- Max Staley: Seahawks

Ravens vs Broncos Picks

Ravens (+1) vs Broncos (-1) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Ravens
- Taylor McKillop: Ravens
- David Kaestle: Broncos
- Isaiah De Los Santos: Broncos
- Jason Schandl: Broncos
- Max Staley: Ravens

Steelers vs Packers Picks

Steelers (+7) vs Packers (-7) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Packers
- Taylor McKillop: Packers
- David Kaestle: Packers
- Isaiah De Los Santos: Packers
- Jason Schandl: Steelers
- Max Staley: Packers

Buccaneers vs Patriots Picks

Buccaneers (-6.5) vs Patriots (+6.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Buccaneers
- Taylor McKillop: Buccaneers
- David Kaestle: Buccaneers
- Isaiah De Los Santos: Buccaneers
- Jason Schandl: Patriots
- Max Staley: Buccaneers

Raiders vs Chargers Picks

Raiders (+3.5) vs Chargers (-3.5) Betting Preview

Staff Picks (ATS):
- Brian Giuffra: Chargers
- Taylor McKillop: Raiders
- David Kaestle: Raiders
- Isaiah De Los Santos: Chargers
- Jason Schandl: Chargers
- Max Staley: Raiders

Staff Records (ATS):
- Isaiah De Los Santos: 27-20 (57.45%)
- Brian Giuffra: 17-15 (53.13%)
- Max Staley: 24-23 (51.06%)
- Taylor McKillop: 24-23 (51.06%)
- David Kaestle: 22-25 (46.81%)
- Jason Schandl: 19-28 (40.43%)

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David Kaestle is not a FanDuel employee. In addition to providing DFS gameplay advice, David also participates in DFS contests on FanDuel using his personal account, username davekaestle. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.