3 Hardest Games on the Cardinals Schedule in 2022

A look at the three hardest games on the Arizona Cardinals schedule in 2022.
A look at the three hardest games on the Arizona Cardinals schedule in 2022. / David Wallace/The Republic via Imagn

Every team in the NFL already knows which teams they will be facing during the 2022 season, just not the specific dates and start times. That will be revealed at 8 p.m. ET on NFL Network on May 12. The Arizona Cardinals also know that their schedule is one of the toughest ones in the entire league.

Both Mike Clay of ESPN and Zach Koons of Sports Illustrated highlighted just how difficult Arizona's road to a potential playoff berth is going to be. Head coach Kliff Kingsbury is going to have his work cut out for him, so let's take a look at the three hardest matchups the Cardinals will have in 2022.

Arizona Cardinals 2022 Schedule

1. @ Los Angeles Rams

The Cardinals suffered a brutal Wild Card round loss at the hands of the Los Angeles Rams last postseason. The score ended up being 34-11 as LA caused a ton of issues by forcing turnovers and marching down the field with ease on offense. Kyler Murray has made headlines this offseason as he continues to express that he is tired of losing. That motivation coupled with the fact that he is 1-5 straight up in his career against the Rams makes this a game to circle on the calendar. It has a primetime slot written all over it as Matthew Stafford looks to lead his team to back-to-back Super Bowl titles.

2. vs Kansas City Chiefs

It's noteworthy to point out that not only has Kyler Murray never faced the Kansas City Chiefs, and Patrick Mahomes has only faced the Arizona Cardinals once. The unfamiliarity between these two teams should make for an exciting game at State Farm Stadium. Don't get it twisted, though. The Chiefs will likely still enter this game as a favorite and have posted a combined record of 50-15 over the last four seasons. The Cardinals will have to find a way to shut down tight end Travis Kelce if they want any shot of winning this one. The 32-year-old has logged at least 1,000 yards and 4 touchdowns in six consecutive seasons.

3. @ Denver Broncos

Traveling to Empower Field at Mile High was already going to be a tough task for a Cardinals team that has lost nine of its last 10 games to the Broncos. Throwing in the fact that Russell Wilson is now the team's starting quarterback only adds to the likelihood of another loss. Wilson is 11-8-1 against Arizona in his career and has thrown 32 touchdowns compared to 9 interceptions during that span. On the other side of the football, Denver added linebacker Randy Gregory to a defense that finished second in opponent points per game in 2021 (18.9). The Cardinals will have to be firing on all cylinders to earn a gutsy road win here.

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.