Full 49ers 2022 Schedule: List of San Francisco Opponents This NFL Season

The 2022-23 NFL regular season schedule will be released on Thursday, May 12. The official release will let the San Francisco 49ers know when and where they'll play throughout the year, since they already know who their opponents are.

2022 49ers Schedule

Here's everything we know so far about the 49ers' schedule in 2022.

San Francisco 49ers Football Schedule 2022

San Francisco will find out its entire schedule for the 2022-23 regular season on Thursday, May 12. The official schedule release is slated to air on NFL Network at 8 p.m. ET. This article will be updated once the full schedule has been released.

49ers Week 1 Opponent

The San Francisco 49ers' Week 1 matchup has not been officially revealed yet. Last season, they opened with a road game against the Detroit Lions on Sunday, Sept. 12, 2021.

49ers 2022 Strength of Schedule

According to ESPN's Mike Clay, the 49ers have the 14th-easiest schedule in the NFL for the 2022 campaign.

49ers Home Games 2022

- Seattle Seahawks
- Los Angeles Rams
- Arizona Cardinals
- Kansas City Chiefs
- Los Angeles Chargers
- Miami Dolphins
- New Orleans Saints
- Tampa Bay Buccaneers
- Washington Commanders

49ers Away Games 2022

- Seattle Seahawks
- Los Angeles Rams
- Arizona Cardinals
- Atlanta Falcons
- Carolina Panthers
- Chicago Bears
- Denver Broncos
- Las Vegas Raiders

49ers Opponents Record 2022

The 49ers' opponents went 154-135 during the 2021-22 NFL season.

49ers International Game 2022

The 49ers are one of 10 teams playing in an international game during the 2022-23 regular season. San Francisco will be the "road" team against the Arizona Cardinals on Nov. 21 at Estadio Azteca in Mexico City, Mexico.

49ers Super Bowl Odds

The 49ers are currently +1600 (T-No. 6) in FanDuel Sportsbook's latest Super Bowl odds.

49ers Win Total Odds

San Francisco is listed with a win total of 9.5 for the 2022-23 regular season. The 49ers are -145 to hit the over, and +125 to hit the under.

49ers Win Total Prediction 2022

After an injury-plagued 2020 campaign, the 49ers bounced back with an NFC Championship Game appearance in 2021. San Francisco should remain a championship threat heading into 2022, with the potential of being elite on both offense and defense. The 49ers' success could come down to how well Trey Lance can perform as the starting QB, but even then it's hard not imagining them hitting at least 10 wins this season.

Bet – 49ers: Over 9.5 Wins (-145)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.