Fresno State vs USC Prediction, Odds & Betting Trends for College Football Week 3 Game on FanDuel Sportsbook

Fresno State vs. USC prediction, odds and betting trends for NCAA college football game.
Fresno State vs. USC prediction, odds and betting trends for NCAA college football game. / AP Photos/Marcio Jose Sanchez

Fresno State vs USC Week 3 Game Info

2022 NCAA College Football Game
Fresno State Bulldogs (1-1) vs. No. 7 USC Trojans (2-0)
Date: Saturday, Sept. 17, 2022
Time: 10:30 p.m. ET
Venue: Los Angeles Memorial Coliseum — Los Angeles, CA
Coverage: FOX

Week 3 of the 2022 NCAA college football season includes a showdown between the Fresno State Bulldogs and No. 7 USC Trojans. After winning in Week 1, the Bulldogs tasted defeat in their second, game, suffering a 35-32 loss to Oregon State.

Meanwhile, it was business as usual for the Trojans. A 41-28 victory over Stanford gave USC its second win of the season, highlighted by quarterback Caleb Williams completing 20 passes for 341 yards and four touchdowns. Wideout Jordan Addison caught seven of those passes for 172 receiving yards and a pair of scores.

Fresno State vs USC Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: FRES: (+330) | USC: (-430)
Spread: FRES: +10.5 (-110) | USC: -10.5 (-110)
Total: 74.5 — Over: (-110) | Under: (-110)

USC enters this contest as the favorite on the spread. This 10:30 p.m. ET clash also features a total of 74.5, which is the highest projected total of the week.

Fresno State vs USC Prediction & Pick

The Fresno State-USC head-to-head matchups have leaned towards one school more than the other over the years. While the Bulldogs won the inaugural meeting in 1992, the Trojans have won each of the four collisions since then, scoring an average of 44.5 points while only allowing 24.5.

USC is the clear-cut better team here and winning shouldn't be difficult. Another reason to like the Trojans is because of their going 12-0 straight up against their last 12 Mountain West opponents. Throw in Fresno State's shortcomings last week and it isn't tough to see why USC will win on Sunday.

Final Score Prediction: USC: 42 | Fresno State: 24

Fresno State vs USC Betting Trends

- Fresno State is 2-4 against the spread (ATS) in its last six games.
- USC is 4-0 straight up in its last four games against Fresno State.
- The total has hit the under in four of Fresno State's last six games.
- The total has hit the over in each of USC's last seven home games.

Fresno State vs USC Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

While covering a 10.5-point spread is tough for some programs, that isn't the case for USC. The Trojans have already won both of their first two games by at least 13 points and the fact that they've beaten Fresno State by an average of 20 points in the last four games only strengthens their odds to cover the spread.

Don't underestimate USC here. Take them to cover the 10.5-point spread at -110 odds.

Bet: USC -10.5 (-110)

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Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.