NFL - Odds & Predictions

Colts vs Cardinals Prediction, Odds, Spread, Over/Under & Betting Trends for NFL Week 16 Game on FanDuel Sportsbook

Devon Platana
Indianapolis Colts vs Arizona Cardinals prediction, odds, spread, over/under and betting trends for NFL Week 16 game.
Indianapolis Colts vs Arizona Cardinals prediction, odds, spread, over/under and betting trends for NFL Week 16 game. / Justin Casterline/GettyImages
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Colts vs Cardinals Week 16 Game Info

NFL Regular Season — Week 16 Game
Indianapolis Colts (8-6, 4-2 Away) vs. Arizona Cardinals (10-4, 3-3 Home)
Date: Saturday, December 25, 2021
Time: 8:15 p.m. EST
Venue: State Farm Stadium — Glendale, AZ
Coverage: NFL Network

Colts vs Cardinals Odds & Spread

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: IND: (+102) | ARI: (-118)
Spread: IND: +1.5 (-110) | ARI: -1.5 (-110)
Total: 49.5 — Over: (-110) | Under: (-110)
Odds to Win Super Bowl LVI: IND: (+1900) | ARI: (+1500)

Colts vs Cardinals Prediction & Pick

All NFL predictions and picks are from numberFire's projection model and will be updated when available.
Prediction: Arizona Cardinals win (53.8%)

Colts vs Cardinals Betting Trends

- Indianapolis is 5-0 against the spread (ATS) in its last five road games.
- Arizona is 3-8 ATS in its last 11 home games.
- The total has hit the over in five of Indianapolis' last six games against NFC opponents.
- The total has hit the under in six of Arizona's last seven games against Indianapolis.


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Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.

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