Cardinals vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 21

Duel Staff
Cardinals vs Pirates odds, probable pitchers and prediction for MLB game on Saturday, May 21.
Cardinals vs Pirates odds, probable pitchers and prediction for MLB game on Saturday, May 21. / Charles LeClaire-USA TODAY Sports

On Saturday in the MLB, the St. Louis Cardinals are up against the Pittsburgh Pirates.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Cardinals vs Pirates Game Info

  • St. Louis Cardinals (21-18) vs. Pittsburgh Pirates (16-22)
  • Date: Saturday, May 21, 2022
  • Time: 6:35 PM ET
  • Venue: PNC Park -- Pittsburgh, Pennsylvania

Cardinals vs Pirates Odds & Moneyline

  • All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
  • Moneyline: STL: (-138) | PIT: (+118)
  • Spread: STL: -1.5 (+116) | PIT: +1.5 (-140)
  • Total: 8.5 -- Over: (-120) | Under: (-102)

Cardinals vs Pirates Probable Starting Pitchers

The Cardinals will start Matthew Liberatore versus the Pirates and Jose Quintana (1-1).

Cardinals vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (50.7%)

Cardinals vs Pirates Moneyline

  • The Cardinals vs Pirates moneyline has St. Louis as a -138 favorite, while Pittsburgh is a +118 underdog at home.

Cardinals vs Pirates Spread

  • The Pirates are +1.5 on the runline against the Cardinals. The Pirates are -140 to cover, and the Cardinals are +116.

Cardinals vs Pirates Over/Under

  • An over/under of 8.5 has been set for Cardinals-Pirates on May 21, with the over being -120 and the under -102.

Cardinals vs Pirates Betting Trends

  • The Cardinals have been victorious in 11, or 64.7%, of the 17 contests they have been chosen as favorites in this season.
  • St. Louis has a mark of 9-5 in contests where bookmakers favor them by -136 or better on the moneyline.
  • St. Louis and their opponents have hit the over in 20 of their 39 games with a total set by oddsmakers this season.
  • The Pirates have been the underdog on the moneyline 31 total times this season. They've gone 12-19 in those games.
  • When playing as a moneyline underdog with odds of +116 or longer, Pittsburgh has an 8-16 record (winning only 33.3% of its games).
  • Pittsburgh has had an over/under set by oddsmakers 38 times, and has combined with opponents to go over the total in 14 of those games (14-19-5).

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