NFL - Odds & Predictions

Bills vs Saints Prediction, Odds, Spread, Over/Under & Betting Trends for NFL Week 12 Thanksgiving Game on FanDuel

Larry Rupp
Buffalo Bills vs New Orleans Saints prediction, odds, spread, over/under and betting trends for NFL Week 12 game.
Buffalo Bills vs New Orleans Saints prediction, odds, spread, over/under and betting trends for NFL Week 12 game. / Kevin Hoffman/GettyImages
facebooktwitterreddit

Bills vs Saints Week 12 Game Info

NFL Regular Season — Week 12 Game
Buffalo Bills (6-4, 3-2 Away) vs. New Orleans Saints (5-5, 2-2 Home)
Date: Thursday, November 25, 2021
Time: 8:20 p.m. EST
Venue: Caesars Superdome — New Orleans, LA
Coverage: NBC

Bills vs Saints Spread & Odds

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: BUF: (-260) | NO: (+215)
Spread: BUF: -6.5 (-112) | NO: +6.5 (-108)
Total: 45 — Over: (-110) | Under: (-110)
Odds to Win Super Bowl LVI: BUF: (+900) | NO: (+7500)

Bills vs Saints Prediction & Pick

All NFL predictions and picks are from numberFire's projection model.
Prediction: Buffalo Bills 60.2%

Bills vs Saints Betting Trends

- Buffalo is 13-6-1 against the spread (ATS) in its last 20 games.
- The total has hit the over in four of Buffalo's last six games.
- New Orleans is 5-0 straight up in its last five games against Buffalo.
- The total has hit the over in four of New Orleans' last five games.


Sign up for FanDuel Sportsbook today and get your first bet risk free for up to $1,000!


Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

facebooktwitterreddit