The two positional groups that are responsible for most touchdowns are running backs and wide receivers.
Generally, these guys get it done on the ground or in the air, but
Odds on Most #NFL Regular Season Rushing + Receiving TDs (player) via FanDuel:— TheDuel (@TheDuelSports) August 31, 2018
Todd Gurley +650
Ezekiel Elliott +670
Alvin Kamara +790
David Johnson +790
Kareem Hunt +870
Leonard Fournette +870
Le'Veon Bell +870
DeAndre Hopkins +900
Melvin Gordon +960
Odell Beckham Jr. + 960
Generally, running backs will be the better bets here simply because they have chances to score both rushing and receiving touchdowns, while most wide receivers won't score any of the sort. In the last 10 years, a wide receiver has only finished with the most touchdowns of any kind once, and that was in 2015 when there was a four-way tie between Brandon Marshall, Doug Baldwin, Allen Robinson and Devonta Freeman, all with 14 touchdowns.
To truly get the most value out of a pick in this scenario, you have to go with a running back who catches a lot of passes out of the backfield. This isn't necessarily an auto-win, as running backs like LeGarrette Blount have come close with nothing but rushing touchdowns in recent years, but it's much safer.
It's a bit boring, but Todd Gurley, Alvin Kamara and David Johnson are the best bets here. Ezekiel Elliott is a beast in rushing touchdowns, but he only has three career receiving touchdowns, setting him back further from the pack. Gurley had an astonishing 19 touchdowns last season, with six of them coming through the air. Kamara had 13, with five coming in the passing game, and will look to see even more action in the early going with Mark Ingram suspended. Lastly, Johnson was hurt last season but led the league with 20 touchdowns in 2016.
Gurley is the most likely to win you this prop bet and become the first repeat winner since Shaun Alexander in 2005. But in terms of better odds, it might be smarter to lean towards David Johnson's return to dominance.
No matter which way you go, just remember to pick a running back.
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Ian McCafferty is not a FanDuel employee. In addition to providing DFS gameplay advice, Ian McCafferty also participates in DFS contests on FanDuel using his personal account, username