49ers vs Rams Point Spread, Over/Under, Moneyline and Betting Trends for NFL Week 18 Game

Week 18's slate of games includes an NFC West showdown between the San Francisco 49ers and Los Angeles Rams.

Here's everything you need to know before placing your bet for this game on FanDuel Sportsbook.

49ers vs Rams Point Spread

The Rams are 4.5-point home favorites against the 49ers. The Rams are -108 to cover the spread, while San Francisco is -112 to cover as a 4.5-point underdog.

49ers vs Rams Over/Under

The over/under for the 49ers vs Rams Week 18 NFL matchup is set at 44.5, with -110 odds on the over and -110 odds on the under.

49ers vs Rams Moneyline

The 49ers vs Rams moneyline has the Rams as -200 favorites, while San Francisco is a +168 underdog on the road.

49ers vs Rams Betting Trends

- San Francisco is 5-0 straight up in its last five games against the Rams.
- The Rams are 3-7 against the spread (ATS) in their last 10 games against San Francisco.
- The total has hit the under in six of San Francisco's last eight games.
- The total has hit the under in 12 of the Rams' last 15 home games.

49ers vs Rams Prediction

All NFL predictions and picks are from numberFire's projection model.
Prediction: Los Angeles Rams win (57.2%)

49ers vs Rams Odds

All NFL regular betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (+168) | LAR: (-200)
Spread: SF: +4.5 (-112) | LAR: -4.5 (-108)
Total: 44.5 — Over: (-110) | Under: (-110)
Odds to Win Super Bowl LVI: SF: (+3400) | LAR: (+950)

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Devon Platana is not a FanDuel employee. The views expressed in his articles are the author's alone and do not necessarily reflect the views of FanDuel.