49ers vs Rams Opening Odds, Betting Lines and Prediction for Week 18 Game on FanDuel Sportsbook

San Francisco 49ers vs Los Angeles Rams NFL opening odds, lines and predictions for Week 18 matchup.
San Francisco 49ers vs Los Angeles Rams NFL opening odds, lines and predictions for Week 18 matchup. / Lachlan Cunningham/GettyImages
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Week 17 NFL action has yet to wrap up, but FanDuel Sportsbook has already released NFL odds and lines for Week 18, giving us an early preview of next week's games.

Week 18's slate features an NFC West clash between the San Francisco 49ers and Los Angeles Rams.

49ers vs Rams Odds & Lines Week 18

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (+198) | LAR: (-240)
Spread: SF: +6 (-110) | LAR: -6 (-110)
Total: N/A — Over: (N/A) | Under: (N/A)

49ers vs Rams Prediction Week 18

Early NFL predictions and picks are from ESPN's Football Power Index (FPI).
49ers: 35.3% to win
Rams: 64.4% to win


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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.