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49ers vs Lions Spread, Odds, Line, Over/Under, Prediction and Betting Insights for NFL Week 1 Game

Larry Rupp
San Francisco 49ers vs Detroit Lions prediction, odds, over, under, spread and prop bets for Week 1 NFL game.
San Francisco 49ers vs Detroit Lions prediction, odds, over, under, spread and prop bets for Week 1 NFL game. / Adam Glanzman/Getty Images
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49ers vs Lions Week 1 Game Info

NFL Week 1 Game
San Francisco 49ers (0-0, 0-0 Away) vs. Detroit Lions (0-0, 0-0 Home)
Date: Sunday, Sep. 12, 2021
Time: 1 p.m. EST
Venue: Ford Field — Detroit, MI
Coverage: FOX

49ers vs Lions Spread & Odds

All NFL betting lines, odds, and prop bets are available on FanDuel Sportsbook.
Moneyline: SF: (-370) | DET: (+295)
Spread: SF: -7.5 (-110) | DET: +7.5 (-110)
Total: 45.5 – Over: (-110) | Under: (-110)
Public (Spread) Betting Percentages via oddsFire: SF: (N/A) | DET: (N/A)
Odds to Win Super Bowl LV: SF: (+1300) | DET: (+15000)

49ers vs Lions Expert Prediction & Pick

All 49ers-Lions expert predictions and picks will be updated when available.

49ers vs Lions Betting Trends

- San Francisco went 7-9 against the spread (ATS) last season.
- The total hit the over in eight of San Francisco's 16 games last season.
- Detroit went 7-9 ATS last season.
- The total hit the over in 10 of Detroit's 16 games last season.

49ers vs Lions Stats

- San Francisco averaged 23.5 points per game (PPG) last season (No. 21 in the NFL).
- San Francisco surrendered 24.4 PPG last season (No. 17 in the NFL).
- Detroit averaged 23.6 PPG last season (No. 20 in the NFL).
- Detroit surrendered 32.4 PPG last season (No. 32 in the NFL).


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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

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