49ers vs Giants Point Spread, Over/Under, Moneyline and Betting Trends for NFL Week 3

The injury-depleted San Francisco will take on the New York Giants at MetLife Stadium in this Week 3 game on Sept. 27.

Here's everything you need to know before placing your bet for this game on FanDuel Sportsbook.

49ers vs Giants Point Spread

The San Francisco 49ers are 4.5-point road favorites in Week 3, with +100 odds. The Giants are 4.5-home underdogs, with -120 odds to cover the spread.

49ers vs Giants Over/Under

The over/under for the 49ers vs Giants matchup in Week 3 is set at 41.0, with -110 odds on both the over and under.

49ers vs Giants Moneyline

The 49ers vs Giants moneyline has San Francisco as a -200 road favorite, while the Giants are a +168 home underdog.

49ers vs Giants Betting Trends

- San Francisco is 4-2 against the spread (ATS) in its last six games.
- San Francisco is 3-7 straight up in its last 10 games against the Giants.
- The Giants are 4-2 ATS in their last six games.
- The Giants are 1-6 ATS in their last seven home games.

49ers vs Giants Odds

All betting lines, odds and prop bets are available on FanDuel Sportsbook.
Moneyline: SF: (-200) | NYG: (+168)
Spread: SF: -4.5 (+100) | NYG: +4.5 (-120)
Total: 41 – Over: (-110) | Under: (-110)
Public (Spread) Betting Percentages via oddsFire: SF: (74%) | NYG: (26%)
Odds to Win Super Bowl LV: SF: (+1200) | NYG: (+12000)

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