NFL - Odds & Predictions

49ers vs Chargers Prediction, Odds, Spread, Over/Under & Betting Trends for NFL Preseason Week 2 Game on FanDuel

Larry Rupp
San Francisco 49ers vs Los Angeles Chargers prediction, odds, spread, over/under and betting trends for NFL Preseason Week 2 Game.
San Francisco 49ers vs Los Angeles Chargers prediction, odds, spread, over/under and betting trends for NFL Preseason Week 2 Game. / Thearon W. Henderson/Getty Images
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49ers vs Chargers Preseason Game Info

NFL Preseason — Week 2 Game
San Francisco 49ers (0-1) vs. Los Angeles Chargers (1-0)
Date: Sunday, August 22, 2021
Time: 7:30 p.m. EST
Venue: SoFi Stadium — Inglewood, CA
Coverage: NFL Network

49ers vs Chargers Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook and will be updated when available.
Moneyline: SF: (-140) | LAC: (+120)
Spread: SF: -2.5 (-110) | LAC: +2.5 (-110)
Total: N/A — Over: (N/A) | Under: (N/A)

49ers vs Chargers Prediction & Pick

Prediction: San Francisco is projected to defeat the Chargers according to the betting odds on FanDuel Sportsbook.

49ers vs Chargers Betting Trends

- San Francisco is 14-5 straight up in its last 19 away games.
- The total has hit the over in four of San Francisco's last five games against the Chargers.
- The Chargers are 5-0 against the spread (ATS) in their last five games.
- The total has hit the under in 14 of the Chargers' last 19 home games.


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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

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