NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 8

The NFL lineup in Week 8 is not one to miss. The outings include the San Francisco 49ers taking on the Houston Texans at NRG Stadium.

To gain an edge ahead of Week 8 in the NFL, check out our betting preview below.

Chargers vs. Vikings

The Los Angeles Chargers (4-3) and the Minnesota Vikings (3-3), who both lost their last game, will go head to head at 8:15 p.m. ET on Thursday, Oct. 23. In their previous games, the Chargers lost 38-24 to the Colts, and the Vikings were taken down by the Eagles 28-22.

• Game Preview: Minnesota Vikings at Los Angeles Chargers
• Projected Favorite: Chargers (54.61% win probability)
• Spread: Los Angeles (-3.5)
• Total: 44.5 -- Over: (-112) | Under: (-108)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Los Angeles vs. Minnesota with FanDuel Sportsbook.

Ravens vs. Bears

The Baltimore Ravens (1-5) are set to square off against the Chicago Bears (4-2) at M&T Bank Stadium on Sunday, Oct. 26 at 1 p.m. ET. In their last contests, the Ravens were defeated by the Rams 17-3, and the Bears won 26-14 against the Saints.

• Game Preview: Chicago Bears at Baltimore Ravens
• Projected Favorite: Bears (56.86% win probability)
• Spread: Baltimore (-2.5)
• Total: 44.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Baltimore vs. Chicago with FanDuel Sportsbook.

Patriots vs. Browns

Drake Maye will lead the New England Patriots (5-2) into their game against the Cleveland Browns (2-5) at Gillette Stadium on Sunday at 1 p.m. ET.

• Game Preview: Cleveland Browns at New England Patriots
• Projected Favorite: Patriots (83.01% win probability)
• Spread: New England (-7)
• Total: 40.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New England vs. Cleveland with FanDuel Sportsbook.

Panthers vs. Bills

Star running back James Cook and the Buffalo Bills (4-2) face the Carolina Panthers (4-3) on Sunday at 1 p.m. ET at Bank of America Stadium.

• Game Preview: Buffalo Bills at Carolina Panthers
• Projected Favorite: Bills (62.57% win probability)
• Spread: Buffalo (-7.5)
• Total: 47.5 -- Over: (-106) | Under: (-114)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Buffalo with FanDuel Sportsbook.

Falcons vs. Dolphins

At Mercedes-Benz Stadium on Sunday, Bijan Robinson and the Atlanta Falcons (3-3) play De'Von Achane and the Miami Dolphins (1-6) in a matchup featuring a pair of outstanding running backs, beginning at 1 p.m. ET.

• Game Preview: Miami Dolphins at Atlanta Falcons
• Projected Favorite: Falcons (73.37% win probability)
• Spread: Atlanta (-6.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Atlanta vs. Miami with FanDuel Sportsbook.

Eagles vs. Giants

A pair of the best offensive players in football will be featured when quarterback Jalen Hurts and the Philadelphia Eagles (5-2) host running back Cam Skattebo and the New York Giants (2-5) on Sunday, October 26, 2025.

• Game Preview: New York Giants at Philadelphia Eagles
• Projected Favorite: Eagles (72.87% win probability)
• Spread: Philadelphia (-7.5)
• Total: 43.5 -- Over: (-118) | Under: (-104)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Philadelphia vs. New York with FanDuel Sportsbook.

Bengals vs. Jets

Ja'Marr Chase will lead the Cincinnati Bengals (3-4) into their battle versus the New York Jets (0-7) at Paycor Stadium on Sunday at 1 p.m. ET.

• Game Preview: New York Jets at Cincinnati Bengals
• Projected Favorite: Bengals (66.25% win probability)
• Spread: Cincinnati (-5.5)
• Total: 44.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Cincinnati vs. New York with FanDuel Sportsbook.

Texans vs. 49ers

The 1 p.m. ET game on Oct. 26 between the San Francisco 49ers (5-2) and the Houston Texans (2-4) should be a fun matchup, as Christian McCaffrey has been one of the league's top receivers this season, and the Texans have been a top-five pass defense, ranking fifth-best in the NFL with 179.0 passing yards allowed per game.

• Game Preview: San Francisco 49ers at Houston Texans
• Projected Favorite: Texans (66.04% win probability)
• Spread: Houston (-2.5)
• Total: 41.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Houston vs. San Francisco with FanDuel Sportsbook.

Saints vs. Buccaneers

The Tampa Bay Buccaneers (5-2), who were taken down by the Lions in their last game, visit the New Orleans Saints (1-6) at Caesars Superdome on Oct. 26 at 4:05 p.m. ET. The Saints lost to the Bears in their last game.

• Game Preview: Tampa Bay Buccaneers at New Orleans Saints
• Projected Favorite: Buccaneers (65.56% win probability)
• Spread: Tampa Bay (-3.5)
• Total: 46.5 -- Over: (-106) | Under: (-114)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on New Orleans vs. Tampa Bay with FanDuel Sportsbook.

Colts vs. Titans

Sunday's game between the Indianapolis Colts (6-1) and the Tennessee Titans (1-6) could be one-sided, as the Colts sport the best scoring offense in the league, while the Titans' offense ranks at the very bottom. Kickoff is at 4:25 p.m. ET on Oct. 26.

• Game Preview: Tennessee Titans at Indianapolis Colts
• Projected Favorite: Colts (90.17% win probability)
• Spread: Indianapolis (-14.5)
• Total: 47.5 -- Over: (-114) | Under: (-106)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Indianapolis vs. Tennessee with FanDuel Sportsbook.

Broncos vs. Cowboys

Sunday's tilt between the Dallas Cowboys (3-3-1) and the Denver Broncos (5-2) should be competitve, as the Cowboys sport the second-ranked scoring offense in the league (31.7 points per game), and the Broncos are surrendering 18.1 points per contest (fourth in NFL). The game is scheduled to begin at 4:25 p.m. ET on Oct. 26.

• Game Preview: Dallas Cowboys at Denver Broncos
• Projected Favorite: Broncos (65.17% win probability)
• Spread: Denver (-3.5)
• Total: 51.5 -- Over: (-106) | Under: (-114)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Denver vs. Dallas with FanDuel Sportsbook.

Steelers vs. Packers

Tucker Kraft will lead the Green Bay Packers (4-1-1) into their game versus the Pittsburgh Steelers (4-2) at Acrisure Stadium on Sunday at 8:20 p.m. ET.

• Game Preview: Green Bay Packers at Pittsburgh Steelers
• Projected Favorite: Packers (51.08% win probability)
• Spread: Green Bay (-2.5)
• Total: 45.5 -- Over: (-110) | Under: (-110)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Pittsburgh vs. Green Bay with FanDuel Sportsbook.

Chiefs vs. Commanders

Star quarterback Patrick Mahomes and the Kansas City Chiefs (4-3) face the Washington Commanders (3-4) on Monday at 8:15 p.m. ET at GEHA Field at Arrowhead Stadium.

• Game Preview: Washington Commanders at Kansas City Chiefs
• Projected Favorite: Chiefs (80.75% win probability)
• Spread: Kansas City (-11.5)
• Total: 47.5 -- Over: (-115) | Under: (-105)
• Time: 8:15 p.m. ET
• Channel: ABC/ESPN

Bet on Kansas City vs. Washington with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!