Trail Blazers vs. Timberwolves Prediction, Odds, Picks, Best Bets for Oct. 22

Trail Blazers vs. Timberwolves Game Info

• Date: Wednesday, October 22, 2025
• Time: 10 p.m. ET
• Venue: Moda Center -- Portland, Oregon
• Coverage: KUNP and FDSN

In the first game of the 2025-26 season for both teams, the Minnesota Timberwolves visit the Portland Trail Blazers at Moda Center, beginning at 10 p.m. ET on Wednesday, October 22, 2025. The Trail Blazers are 4.5-point underdogs in the game. The matchup's over/under is 221.5.

Trail Blazers vs. Timberwolves Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Trail Blazers vs. Timberwolves Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction:

Trail Blazers vs. Timberwolves Betting Trends

• The Timberwolves covered 39 times in 82 matchups with a spread last season.
• As 4.5-point underdogs or greater, the Trail Blazers went 29-23-1 against the spread last year.
• A total of 45 Timberwolves games last season went over the point total.
• The Trail Blazers had 40 of their 82 games go over the point total last year.
• Minnesota had a worse record against the spread at home (17-23-1) than it did in away games (22-19-0) last season.
• Last year, Portland was 24-17-0 at home against the spread (.585 winning percentage). Away, it was 22-18-1 ATS (.537).

Timberwolves Leaders

• Per game, Anthony Edwards put up points, 5.7 rebounds and 4.5 assists last year. He also put up 1.2 steals and 0.6 blocks.
• Julius Randle's numbers last season were 18.7 points, 7.1 rebounds and 4.7 assists per game. He drained 48.5% of his shots from the floor and 34.4% from beyond the arc, with an average of 1.6 triples.
• Rudy Gobert averaged 12 points, 10.9 boards and 1.8 assists. He made 66.9% of his shots from the floor (third in NBA).
• Naz Reid put up 14.2 points, 6 boards and 2.3 assists. He drained 46.2% of his shots from the field and 37.9% from 3-point range, with 2.2 treys per contest.
• Jaden McDaniels' stats last season included 12.2 points, 5.7 boards and 2 assists per game. He sank 47.7% of his shots from the field and 33% from 3-point range, with an average of 1.2 treys.

Trail Blazers Leaders

• Damian Lillard recorded 24.9 points, 4.7 boards and 7.1 assists last year, shooting 44.8% from the floor and 37.6% from beyond the arc, with 3.4 made 3-pointers per game (seventh in league).
• Deni Avdija's numbers last season were 16.9 points, 7.3 boards and 3.9 assists per contest, shooting 47.6% from the field and 36.5% from downtown, with an average of 1.7 made 3-pointers.
• Shaedon Sharpe recorded 18.5 points, 2.8 assists and 4.5 rebounds.
• Toumani Camara averaged 11.3 points, 5.8 boards and 2.2 assists.
• Scoot Henderson's stats last season were 12.7 points, 3 boards and 5.1 assists per contest, shooting 41.9% from the floor and 35.4% from beyond the arc, with an average of 1.6 made treys.

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