Mavericks vs. Spurs Prediction, Odds, Picks, Best Bets for Oct. 22

Mavericks vs. Spurs Game Info

• Date: Wednesday, October 22, 2025
• Time: 9:30 p.m. ET
• Venue: American Airlines Center -- Dallas, Texas
• Coverage: ESPN

The Dallas Mavericks host the San Antonio Spurs at American Airlines Center, beginning at 9:30 p.m. ET on Wednesday, October 22, 2025. The Mavericks are 2.5-point favorites in the game, the first game of the 2025-26 season for the two squads. The matchup has an over/under of 223.5.

Mavericks vs. Spurs Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Mavericks vs. Spurs Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Mavericks win (64.4%)

Mavericks vs. Spurs Betting Trends

• The Mavericks covered 38 times in 82 chances against the spread last season.
• The Spurs went 25-28 as underdogs of 2.5 points or more last season.
• Last season, the combined scoring went over the point total 46 times in Mavericks games.
• In 82 Spurs games last season, 46 of them went over the total.
• Dallas did a better job covering the spread when playing at home (19-20-1) last season than it did in road affairs (19-22-1).
• San Antonio's winning percentage against the spread at home last year was .512 (21-20-0). On the road, it was .439 (18-23-0).

Mavericks Leaders

• Anthony Davis posted 24.7 points, 11.6 rebounds and 3.5 assists last year. He also drained 51.6% of his shots from the field.
• Last season, Kyrie Irving recorded an average of 24.7 points, 4.8 rebounds and 4.6 assists per game.
• P.J. Washington Jr.'s numbers last season were 14.7 points, 7.8 rebounds and 2.3 assists per game. He sank 45.3% of his shots from the floor and 38.1% from beyond the arc, with an average of 1.6 treys.
• Naji Marshall put up 13.2 points, 4.8 rebounds and 3.0 assists. He sank 50.8% of his shots from the floor.
• Klay Thompson's stats last season included 14.0 points, 3.4 rebounds and 2.0 assists per contest. He drained 41.2% of his shots from the floor and 39.1% from beyond the arc, with an average of 3.0 triples.

Spurs Leaders

• De'Aaron Fox posted 23.5 points, 6.3 assists and 4.8 rebounds last season.
• Victor Wembanyama posted 24.3 points, 11.0 boards and 3.7 assists last season, shooting 47.6% from the field and 35.2% from downtown, with 3.1 made 3-pointers per game.
• Stephon Castle's numbers last season were 14.7 points, 3.7 rebounds and 4.1 assists per contest, shooting 42.8% from the field and 28.5% from downtown, with an average of 1.2 made treys.
• Devin Vassell's stats last season were 16.3 points, 4.0 boards and 2.9 assists per game, shooting 44.3% from the field and 36.8% from beyond the arc, with an average of 2.5 made 3-pointers.
• Keldon Johnson put up 12.7 points, 4.8 rebounds and 1.6 assists.

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