NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 6

In a Week 6 NFL schedule that features a lot of exciting matchups, the San Francisco 49ers versus the Tampa Bay Buccaneers is a game to catch.

Here is the betting info to analyze ahead of Week 6 in the NFL.

Giants vs. Eagles

The Philadelphia Eagles (4-1) and the New York Giants (1-4), who both lost their last contest, will go head to head at 8:15 p.m. ET on Thursday, Oct. 9. In their previous games, the Eagles lost 21-17 to the Broncos, and the Giants were taken down by the Saints 26-14.

• Game Preview: Philadelphia Eagles at New York Giants
• Projected Favorite: Eagles (75.38% win probability)
• Spread: Philadelphia (-7.5)
• Total: 40.5 -- Over: (-118) | Under: (-104)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on New York vs. Philadelphia with FanDuel Sportsbook.

Jets vs. Broncos

Star pass-catcher Garrett Wilson will lead the New York Jets (0-5) into their matchup against the Denver Broncos (3-2) at Tottenham Hotspur Stadium on Sunday at 9:30 a.m. ET.

• Game Preview: Denver Broncos vs. New York Jets
• Projected Favorite: Broncos (79.90% win probability)
• Spread: Denver (-7)
• Total: 43.5 -- Over: (-110) | Under: (-110)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on New York vs. Denver with FanDuel Sportsbook.

Colts vs. Cardinals

Tyler Warren and the Indianapolis Colts (4-1) face the Arizona Cardinals (2-3) on Sunday at 1 p.m. ET, at Lucas Oil Stadium.

• Game Preview: Arizona Cardinals at Indianapolis Colts
• Projected Favorite: Colts (82.41% win probability)
• Spread: Indianapolis (-9.5)
• Total: 46.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Indianapolis vs. Arizona with FanDuel Sportsbook.

Steelers vs. Browns

The Pittsburgh Steelers (3-1) will host the Cleveland Browns (1-4) on Sunday at 1 p.m. ET.

• Game Preview: Cleveland Browns at Pittsburgh Steelers
• Projected Favorite: Steelers (85.18% win probability)
• Spread: Pittsburgh (-5.5)
• Total: 38.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Pittsburgh vs. Cleveland with FanDuel Sportsbook.

Panthers vs. Cowboys

When the Dallas Cowboys (2-2-1) and the Carolina Panthers (2-3) play on Sunday, Oct. 12 at 1 p.m. ET, they will both be looking to stay on track after winning their previous contest. The Cowboys won 37-22 versus the Jets, and the Panthers are coming off a 27-24 victory over the Dolphins.

• Game Preview: Dallas Cowboys at Carolina Panthers
• Projected Favorite: Cowboys (60.65% win probability)
• Spread: Dallas (-3)
• Total: 47.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Dallas with FanDuel Sportsbook.

Saints vs. Patriots

The New Orleans Saints (1-4) play on Sunday at 1 p.m. ET at Caesars Superdome versus the New England Patriots (3-2).

• Game Preview: New England Patriots at New Orleans Saints
• Projected Favorite: Patriots (62.18% win probability)
• Spread: New England (-3.5)
• Total: 45.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New Orleans vs. New England with FanDuel Sportsbook.

Ravens vs. Rams

The Los Angeles Rams (3-2) and Matthew Stafford, one of the NFL's top passers, should have a productive day in the passing game on Sunday, as the Baltimore Ravens (1-4) own the 31st-ranked pass defense in the NFL. The two teams will collide at 1 p.m. ET on Oct. 12.

• Game Preview: Los Angeles Rams at Baltimore Ravens
• Projected Favorite: Rams (60.96% win probability)
• Spread: Los Angeles (-7)
• Total: 43.5 -- Over: (-118) | Under: (-104)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Baltimore vs. Los Angeles with FanDuel Sportsbook.

Dolphins vs. Chargers

The Los Angeles Chargers (3-2) are scheduled to take on the Miami Dolphins (1-4) at Hard Rock Stadium on Sunday, Oct. 12 at 1 p.m. ET. Both squads lost their last tilt, as the Chargers were defeated by the Commanders 27-10, and the Dolphins lost 27-24 to the Panthers.

• Game Preview: Los Angeles Chargers at Miami Dolphins
• Projected Favorite: Chargers (60.68% win probability)
• Spread: Los Angeles (-3.5)
• Total: 44.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Miami vs. Los Angeles with FanDuel Sportsbook.

Jaguars vs. Seahawks

One of the best pass-catchers in football will be on display when Jaxon Smith-Njigba and the Seattle Seahawks (3-2) visit the Jacksonville Jaguars (4-1) on Sunday, October 12, 2025.

• Game Preview: Seattle Seahawks at Jacksonville Jaguars
• Projected Favorite: Seahawks (53.26% win probability)
• Spread: Seattle (-1.5)
• Total: 47.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Jacksonville vs. Seattle with FanDuel Sportsbook.

Raiders vs. Titans

Against the Tennessee Titans (1-4), who own the 30th-ranked run defense this season, Ashton Jeanty and the Las Vegas Raiders (1-4) shouldn't have any trouble running the ball when the two teams square off on Sunday, Oct. 12 at 4:05 p.m. ET. Jeanty has been one of the NFL's top rushers this season, ranking eighth-best in the league in rushing yards.

• Game Preview: Tennessee Titans at Las Vegas Raiders
• Projected Favorite: Raiders (59.69% win probability)
• Spread: Las Vegas (-3.5)
• Total: 41.5 -- Over: (-110) | Under: (-110)
• Time: 4:05 p.m. ET
• Channel: FOX

Bet on Las Vegas vs. Tennessee with FanDuel Sportsbook.

Packers vs. Bengals

Tucker Kraft will lead the Green Bay Packers (2-1-1) into their matchup versus the Cincinnati Bengals (2-3) at Lambeau Field on Sunday at 4:25 p.m. ET.

• Game Preview: Cincinnati Bengals at Green Bay Packers
• Projected Favorite: Packers (86.14% win probability)
• Spread: Green Bay (-14.5)
• Total: 44.5 -- Over: (-115) | Under: (-105)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Green Bay vs. Cincinnati with FanDuel Sportsbook.

Buccaneers vs. 49ers

On Sunday at 4:25 p.m. ET, a pair of outstanding pass-catchers will be on display when Emeka Egbuka and the Tampa Bay Buccaneers (4-1) host Christian McCaffrey and the San Francisco 49ers (4-1).

• Game Preview: San Francisco 49ers at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (71.60% win probability)
• Spread: Tampa Bay (-3.5)
• Total: 46.5 -- Over: (-118) | Under: (-104)
• Time: 4:25 p.m. ET
• Channel: CBS

Bet on Tampa Bay vs. San Francisco with FanDuel Sportsbook.

Chiefs vs. Lions

The Kansas City Chiefs (2-3), who were defeated by the Jaguars in their previous game, host the Detroit Lions (4-1) at GEHA Field at Arrowhead Stadium on Oct. 12 at 8:20 p.m. ET. The Lions defeated the Bengals in their last game.

• Game Preview: Detroit Lions at Kansas City Chiefs
• Projected Favorite: Chiefs (61.44% win probability)
• Spread: Kansas City (-2.5)
• Total: 51.5 -- Over: (-115) | Under: (-105)
• Time: 8:20 p.m. ET
• Channel: NBC

Bet on Kansas City vs. Detroit with FanDuel Sportsbook.

Falcons vs. Bills

One of the best running backs in football will be featured when James Cook and the Buffalo Bills (4-1) visit the Atlanta Falcons (2-2) on Monday, October 13, 2025.

• Game Preview: Buffalo Bills at Atlanta Falcons
• Projected Favorite: Bills (74.53% win probability)
• Spread: Buffalo (-3.5)
• Total: 49.5 -- Over: (-118) | Under: (-104)
• Time: 7:15 p.m. ET
• Channel: ESPN

Bet on Atlanta vs. Buffalo with FanDuel Sportsbook.

Commanders vs. Bears

The Washington Commanders (3-2) play on Monday at 8:15 p.m. ET versus the Chicago Bears (2-2) at Northwest Stadium.

• Game Preview: Chicago Bears at Washington Commanders
• Projected Favorite: Commanders (75.95% win probability)
• Spread: Washington (-5.5)
• Total: 49.5 -- Over: (-115) | Under: (-105)
• Time: 8:15 p.m. ET
• Channel: ABC

Bet on Washington vs. Chicago with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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