NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 10

The Los Angeles Rams and the San Francisco 49ers hit the field in one of many exciting matchups on the NFL slate in Week 10.

If you're looking for additional betting info for Week 10 in the NFL, we've got you covered with betting odds for all the important games.

Broncos vs. Raiders

When the Las Vegas Raiders (2-6) and the Denver Broncos (7-2) compete on Thursday, Nov. 6 at 8:15 p.m. ET, the Raiders' 29th-ranked scoring offense will have its hands full, as the Broncos sport the fourth-ranked defense in the league.

• Game Preview: Las Vegas Raiders at Denver Broncos
• Projected Favorite: Broncos (80.55% win probability)
• Spread: Denver (-8.5)
• Total: 42.5 -- Over: (-112) | Under: (-108)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Denver vs. Las Vegas with FanDuel Sportsbook.

Colts vs. Falcons

At Olympic Stadium Berlin on Sunday, Michael Pittman Jr. and the Indianapolis Colts (7-2) meet Bijan Robinson and the Atlanta Falcons (3-5) in a battle between a pair of the biggest stars in football, starting at 9:30 a.m. ET.

• Game Preview: Atlanta Falcons vs. Indianapolis Colts
• Projected Favorite: Colts (77.27% win probability)
• Spread: Indianapolis (-6.5)
• Total: 48.5 -- Over: (-104) | Under: (-118)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Indianapolis vs. Atlanta with FanDuel Sportsbook.

Texans vs. Jaguars

At 1 p.m. ET on Sunday, the Jacksonville Jaguars (5-3) play at the Houston Texans (3-5).

• Game Preview: Jacksonville Jaguars at Houston Texans
• Projected Favorite: Texans (63.36% win probability)
• Spread: Houston (-1.5)
• Total: 37.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Houston vs. Jacksonville with FanDuel Sportsbook.

Buccaneers vs. Patriots

The Tampa Bay Buccaneers (6-2) host the New England Patriots (7-2) on Sunday at 1 p.m. ET, in a matchup featuring two of the best offensive performers in football in wide receiver Emeka Egbuka and quarterback Drake Maye.

• Game Preview: New England Patriots at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (57.03% win probability)
• Spread: Tampa Bay (-2.5)
• Total: 48.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tampa Bay vs. New England with FanDuel Sportsbook.

Bears vs. Giants

At 1 p.m. ET on Sunday, the Chicago Bears (5-3) are at home against the New York Giants (2-7).

• Game Preview: New York Giants at Chicago Bears
• Projected Favorite: Bears (71.55% win probability)
• Spread: Chicago (-4.5)
• Total: 45.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Chicago vs. New York with FanDuel Sportsbook.

Dolphins vs. Bills

Against the Buffalo Bills (6-2), who sport the 28th-ranked run defense this season, De'Von Achane and the Miami Dolphins (2-7) should have success running the ball when the two teams come together on Sunday, Nov. 9 at 1 p.m. ET. Achane has been one of the NFL's top runners this season, ranking seventh-best in the league in rushing yards.

• Game Preview: Buffalo Bills at Miami Dolphins
• Projected Favorite: Bills (72.54% win probability)
• Spread: Buffalo (-8.5)
• Total: 49.5 -- Over: (-120) | Under: (-102)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Miami vs. Buffalo with FanDuel Sportsbook.

Jets vs. Browns

After going down 32-13 to the Patriots in their previous contest, the Cleveland Browns (2-6) will visit the New York Jets (1-7), who are coming off a 39-38 win over the Bengals. Kickoff is set for 1 p.m. ET on Sunday, Nov. 9.

• Game Preview: Cleveland Browns at New York Jets
• Projected Favorite: Jets (50.21% win probability)
• Spread: Cleveland (-2.5)
• Total: 37.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Cleveland with FanDuel Sportsbook.

Panthers vs. Saints

Star running back Rico Dowdle and the Carolina Panthers (5-4) face the New Orleans Saints (1-8) on Sunday at 1 p.m. ET at Bank of America Stadium.

• Game Preview: New Orleans Saints at Carolina Panthers
• Projected Favorite: Panthers (75.63% win probability)
• Spread: Carolina (-5.5)
• Total: 38.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. New Orleans with FanDuel Sportsbook.

Vikings vs. Ravens

The Baltimore Ravens (3-5) will visit the Minnesota Vikings (4-4) on Sunday at 1 p.m. ET.

• Game Preview: Baltimore Ravens at Minnesota Vikings
• Projected Favorite: Ravens (62.20% win probability)
• Spread: Baltimore (-4.5)
• Total: 48.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Minnesota vs. Baltimore with FanDuel Sportsbook.

Seahawks vs. Cardinals

Jaxon Smith-Njigba will lead the Seattle Seahawks (6-2) into their battle versus the Arizona Cardinals (3-5) at Lumen Field on Sunday at 4:05 p.m. ET.

• Game Preview: Arizona Cardinals at Seattle Seahawks
• Projected Favorite: Seahawks (75.79% win probability)
• Spread: Seattle (-7)
• Total: 44.5 -- Over: (-114) | Under: (-106)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Seattle vs. Arizona with FanDuel Sportsbook.

Commanders vs. Lions

One of the best running backs in football will be featured when Jahmyr Gibbs and the Detroit Lions (5-3) visit the Washington Commanders (3-6) on Sunday, November 9, 2025.

• Game Preview: Detroit Lions at Washington Commanders
• Projected Favorite: Lions (69.29% win probability)
• Spread: Detroit (-7.5)
• Total: 48.5 -- Over: (-118) | Under: (-104)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Washington vs. Detroit with FanDuel Sportsbook.

49ers vs. Rams

On Sunday at 4:25 p.m. ET, a pair of star pass-catchers will be featured when Puka Nacua and the Los Angeles Rams (6-2) visit Christian McCaffrey and the San Francisco 49ers (6-3).

• Game Preview: Los Angeles Rams at San Francisco 49ers
• Projected Favorite: Rams (65.59% win probability)
• Spread: Los Angeles (-5.5)
• Total: 49.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on San Francisco vs. Los Angeles with FanDuel Sportsbook.

Chargers vs. Steelers

The Pittsburgh Steelers (5-3) and their worst pass defense may struggle to stop the Los Angeles Chargers (6-3) and Justin Herbert, one of the league's top passers, when the Steelers visit the Chargers at SoFi Stadium on Nov. 9 at 8:20 p.m. ET.

• Game Preview: Pittsburgh Steelers at Los Angeles Chargers
• Projected Favorite: Chargers (61.20% win probability)
• Spread: Los Angeles (-3)
• Total: 45.5 -- Over: (-106) | Under: (-114)
• Time: 8:20 p.m. ET
• Channel: NBC/Peacock

Bet on Los Angeles vs. Pittsburgh with FanDuel Sportsbook.

Packers vs. Eagles

Josh Jacobs and the Green Bay Packers (5-2-1) will host Jalen Hurts and the Philadelphia Eagles (6-2) on Monday at 8:15 p.m. ET, in a battle featuring a pair of the brightest offensive stars in football.

• Game Preview: Philadelphia Eagles at Green Bay Packers
• Projected Favorite: Packers (67.77% win probability)
• Spread: Green Bay (-1.5)
• Total: 45.5 -- Over: (-110) | Under: (-110)
• Time: 8:15 p.m. ET
• Channel: ABC/ESPN

Bet on Green Bay vs. Philadelphia with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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