NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 5

In a Week 5 NFL slate that features plenty of competitive contests, the San Francisco 49ers versus the Los Angeles Rams is a game to watch.

If you're seeking additional betting info for Week 5 in the NFL, we've got you covered with odds for each of the important games.

Rams vs. 49ers

The Los Angeles Rams (3-1), who grabbed a win against the Colts in their previous game, host the San Francisco 49ers (3-1) at SoFi Stadium on Oct. 2 at 8:15 p.m. ET. The 49ers lost to the Jaguars in their last game.

• Game Preview: San Francisco 49ers at Los Angeles Rams
• Projected Favorite: Rams (60.78% win probability)
• Spread: Los Angeles (-7.5)
• Total: 43.5 -- Over: (-115) | Under: (-105)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Los Angeles vs. San Francisco with FanDuel Sportsbook.

Browns vs. Vikings

At Tottenham Hotspur Stadium on Sunday, the Minnesota Vikings (2-2) play the Cleveland Browns (1-3).

• Game Preview: Minnesota Vikings vs. Cleveland Browns
• Projected Favorite: Vikings (73.34% win probability)
• Spread: Minnesota (-3.5)
• Total: 35.5 -- Over: (-115) | Under: (-105)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Cleveland vs. Minnesota with FanDuel Sportsbook.

Ravens vs. Texans

The Baltimore Ravens (1-3) are in action on Sunday at 1 p.m. ET at M&T Bank Stadium versus the Houston Texans (1-3).

• Game Preview: Houston Texans at Baltimore Ravens
• Projected Favorite: Ravens (65.51% win probability)
• Spread: Houston (-1.5)
• Total: 40.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Baltimore vs. Houston with FanDuel Sportsbook.

Jets vs. Cowboys

The New York Jets (0-4) and Garrett Wilson, one of the NFL's top pass-catchers, should have a big day through the air on Sunday, as the Dallas Cowboys (1-2-1) sport the worst pass defense in the league. The two teams will square off at 1 p.m. ET on Oct. 5.

• Game Preview: Dallas Cowboys at New York Jets
• Projected Favorite: Jets (51.55% win probability)
• Spread: Dallas (-1.5)
• Total: 48.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: FOX

Bet on New York vs. Dallas with FanDuel Sportsbook.

Panthers vs. Dolphins

The Miami Dolphins (1-3), who secured the win against the Jets in their last game, visit the Carolina Panthers (1-3) at Bank of America Stadium on Oct. 5 at 1 p.m. ET. The Panthers lost to the Patriots in their last game.

• Game Preview: Miami Dolphins at Carolina Panthers
• Projected Favorite: Dolphins (55.41% win probability)
• Spread: Miami (-1.5)
• Total: 44.5 -- Over: (+100) | Under: (-122)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. Miami with FanDuel Sportsbook.

Eagles vs. Broncos

The Philadelphia Eagles (4-0) are slated to take on the Denver Broncos (2-2) at Lincoln Financial Field on Sunday, Oct. 5 at 1 p.m. ET. Both teams won their previous game, as the Eagles took down the Buccaneers 31-25, and the Broncos won 28-3 versus the Bengals.

• Game Preview: Denver Broncos at Philadelphia Eagles
• Projected Favorite: Eagles (68.77% win probability)
• Spread: Philadelphia (-4.5)
• Total: 44.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Philadelphia vs. Denver with FanDuel Sportsbook.

Colts vs. Raiders

After going down 27-20 to the Rams in their last tilt, the Indianapolis Colts (3-1) will host the Las Vegas Raiders (1-3), who are coming off a 25-24 loss to the Bears, at Lucas Oil Stadium. Kickoff is set for 1 p.m. ET on Sunday, Oct. 5.

• Game Preview: Las Vegas Raiders at Indianapolis Colts
• Projected Favorite: Colts (73.57% win probability)
• Spread: Indianapolis (-7)
• Total: 47.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Indianapolis vs. Las Vegas with FanDuel Sportsbook.

Saints vs. Giants

When the New Orleans Saints (0-4) and the New York Giants (1-3) match up on Sunday, Oct. 5 at 1 p.m. ET, the Saints will be attempting to rebound from a loss to the Bills, and the Giants will be looking to follow up their recent victory over the Chargers with another win.

• Game Preview: New York Giants at New Orleans Saints
• Projected Favorite: Saints (65.97% win probability)
• Spread: New Orleans (-1.5)
• Total: 41.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New Orleans vs. New York with FanDuel Sportsbook.

Seahawks vs. Buccaneers

One of the top pass-catchers in football will be on display when Emeka Egbuka and the Tampa Bay Buccaneers (3-1) visit the Seattle Seahawks (3-1) on Sunday, October 5, 2025.

• Game Preview: Tampa Bay Buccaneers at Seattle Seahawks
• Projected Favorite: Seahawks (53.63% win probability)
• Spread: Seattle (-3.5)
• Total: 44.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Seattle vs. Tampa Bay with FanDuel Sportsbook.

Cardinals vs. Titans

When the Arizona Cardinals (2-2) and the Tennessee Titans (0-4) square off on Sunday, Oct. 5 at 4:05 p.m. ET, they will both be aiming to rebound after losing their previous contest. The Cardinals lost 23-20 to the Seahawks, and the Titans are coming off a 26-0 loss to the Texans.

• Game Preview: Tennessee Titans at Arizona Cardinals
• Projected Favorite: Cardinals (86.02% win probability)
• Spread: Arizona (-7.5)
• Total: 41.5 -- Over: (-102) | Under: (-120)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Arizona vs. Tennessee with FanDuel Sportsbook.

Chargers vs. Commanders

One of the top pass-catchers in football will be on display when Quentin Johnston and the Los Angeles Chargers (3-1) host the Washington Commanders (2-2) on Sunday, October 5, 2025.

• Game Preview: Washington Commanders at Los Angeles Chargers
• Projected Favorite: Chargers (58.27% win probability)
• Spread: Los Angeles (-2.5)
• Total: 47.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Los Angeles vs. Washington with FanDuel Sportsbook.

Bengals vs. Lions

One of the best pass-catchers in football will be on display when Amon-Ra St. Brown and the Detroit Lions (3-1) visit the Cincinnati Bengals (2-2) on Sunday, October 5, 2025.

• Game Preview: Detroit Lions at Cincinnati Bengals
• Projected Favorite: Lions (77.56% win probability)
• Spread: Detroit (-9.5)
• Total: 49.5 -- Over: (-110) | Under: (-110)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Cincinnati vs. Detroit with FanDuel Sportsbook.

Bills vs. Patriots

One of the top running backs in football will be featured when James Cook and the Buffalo Bills (4-0) host the New England Patriots (2-2) on Sunday, October 5, 2025.

• Game Preview: New England Patriots at Buffalo Bills
• Projected Favorite: Bills (79.07% win probability)
• Spread: Buffalo (-7.5)
• Total: 49.5 -- Over: (-104) | Under: (-118)
• Time: 8:20 p.m. ET
• Channel: NBC

Bet on Buffalo vs. New England with FanDuel Sportsbook.

Jaguars vs. Chiefs

When the Kansas City Chiefs (2-2) and the Jacksonville Jaguars (3-1) match up on Monday, Oct. 6 at 8:15 p.m. ET, they will both be looking to stay on track after winning their last game. The Chiefs won 37-20 against the Ravens, and the Jaguars are coming off a 26-21 victory over the 49ers.

• Game Preview: Kansas City Chiefs at Jacksonville Jaguars
• Projected Favorite: Chiefs (62.86% win probability)
• Spread: Kansas City (-3.5)
• Total: 45.5 -- Over: (-108) | Under: (-112)
• Time: 8:15 p.m. ET
• Channel: ABC/ESPN

Bet on Jacksonville vs. Kansas City with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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